Yi Tian-Xin, Liu Wei, Leng Wen-Fei, Wang Xiao-Chuan, Luo Liang
Department of Rheumatology, Traditional Chinese Medicine Hospital Dianjiang Chongqing, Chongqing 408300, China.
Department of Orthopaedic, Traditional Chinese Medicine Hospital Dianjiang Chongqing, Chongqing 408300, China.
World J Clin Cases. 2024 Feb 16;12(5):1018-1024. doi: 10.12998/wjcc.v12.i5.1018.
Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease. The prevailing theory links AS onset to infections in susceptible individuals. Furthermore, infections may impair the immune responses. Numerous studies have investigated links between AS and various infections-bacterial, viral, fungal, and other microorganism infections. However, limited attention has been given to the association between AS and () infection.
A 27-year-old male with a 10-yr history of AS presented to our hospital with inflammatory lower back pain as the primary manifestation. Ten years ago, the patient had achieved a stable condition after treatment with biological agents. However, he experienced a recurrence of lumbosacral pain with an unexplained cause 10 d before hospital admission. A lumbosacral magnetic resonance imaging (MRI) scan revealed bone marrow edema in the left sacroiliac joint, and laboratory indicators were elevated. Moreover, the presence of eggs was detected in the stool. The patient was prescribed praziquantel, resulting in the disappearance of eggs in subsequent routine stool tests and relief from lumbosacral pain. A follow-up MRI scan performed after 4 months revealed a reduction in bone marrow edema around the left sacroiliac joint.
infections could potentially trigger the exacerbation of AS. Clinicians should pay attention to investigating the presence of infections.
强直性脊柱炎（AS）是一种慢性免疫介导的炎症性疾病。目前流行的理论将AS的发病与易感个体的感染联系起来。此外，感染可能会损害免疫反应。许多研究调查了AS与各种感染（细菌、病毒、真菌和其他微生物感染）之间的联系。然而，AS与（）感染之间的关联却很少受到关注。
一名27岁男性，有10年AS病史，以炎性下背痛为主要表现前来我院就诊。10年前，患者经生物制剂治疗后病情稳定。然而，入院前10天，他出现原因不明的腰骶部疼痛复发。腰骶部磁共振成像（MRI）扫描显示左骶髂关节骨髓水肿，实验室指标升高。此外，粪便中检测到（）虫卵。患者服用吡喹酮后，随后的常规粪便检测中虫卵消失，腰骶部疼痛缓解。4个月后进行的随访MRI扫描显示左骶髂关节周围骨髓水肿减轻。
（）感染可能会引发AS病情加重。临床医生应注意调查是否存在感染。
