Jamall I S, Smith J C
Arch Toxicol. 1985 Dec;58(2):102-5. doi: 10.1007/BF00348317.
Rats fed a basal, low-selenium diet, or this diet supplemented with 0.1 ppm and 1.0 ppm selenium and treated with cadmium, showed significant reductions in the activity of the selenoenzyme glutathione peroxidase in kidney and liver. Cadmium treatment resulted in a significant increase in the activity of selenium-independent glutathione peroxidase activity in the liver of selenium-supplemented rats. Selenium-independent glutathione peroxidase activity was significantly reduced in the kidney of rats fed the basal low-selenium diet. There was no significant increase in lipid peroxidation in any of the groups studied. Cadmium concentrations in the kidney and liver of these animals ranged from about 250 to 700 micrograms Cd/g tissue, dry weight.
喂食基础低硒饮食、或添加了0.1 ppm和1.0 ppm硒并接受镉处理的大鼠，其肾脏和肝脏中的硒酶谷胱甘肽过氧化物酶活性显著降低。镉处理导致补充硒的大鼠肝脏中不依赖硒的谷胱甘肽过氧化物酶活性显著增加。喂食基础低硒饮食的大鼠肾脏中不依赖硒的谷胱甘肽过氧化物酶活性显著降低。在所研究的任何组中脂质过氧化均未显著增加。这些动物肾脏和肝脏中的镉浓度范围为每克组织干重约250至700微克镉。
