Paci Mario, Cardellicchio Pasquale, Di Luzio Paolo, Perrucci Mauro Gianni, Ferri Francesca, Costantini Marcello
Department of Neuroscience, Imaging and Clinical Science, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy.
IIT@UniFe Center for Translational Neurophysiology, Istituto Italiano di Tecnologia, Via Fossato di Mortara, 17-19, 44121 Ferrara, Italy.
iScience. 2024 Feb 5;27(3):109140. doi: 10.1016/j.isci.2024.109140. eCollection 2024 Mar 15.
The phasic cardiovascular activity influences the central nervous system through the systolic baroreceptor inputs, inducing widespread inhibitory effects on behavior. Through transcranial magnetic stimulation (TMS) delivered during resting-state over the left primary motor cortex and across the different cardiac phases, we measured corticospinal excitability (CSE) and distinct indices of intracortical motor inhibition: short (SICI) and long (LICI) interval, corresponding to GABA and GABA neurotransmission, respectively. We found a significant effect of the cardiac phase on short-intracortical inhibition, without any influence on LICI. Specifically, SICI was stronger at systole compared to diastole. These results show a tight relationship between the cardiac cycle and the inhibitory neurotransmission within M1, and in particular with GABA-ergic-mediated motor inhibition. We hypothesize that this process requires greater motor control via the gating mechanism and that this, in turn, needs to be recalibrated through the modulation of intracortical inhibition.
阶段性心血管活动通过收缩期压力感受器输入影响中枢神经系统，对行为产生广泛的抑制作用。通过在静息状态下经颅磁刺激（TMS）作用于左侧初级运动皮层并跨越不同心动周期阶段，我们测量了皮质脊髓兴奋性（CSE）以及皮质内运动抑制的不同指标：短间隔（SICI）和长间隔（LICI），分别对应于GABA和GABA能神经传递。我们发现心动周期阶段对短皮质内抑制有显著影响，而对LICI没有任何影响。具体而言，与舒张期相比，收缩期的SICI更强。这些结果表明心动周期与M1内的抑制性神经传递之间存在紧密关系，特别是与GABA能介导的运动抑制有关。我们推测，这一过程需要通过门控机制进行更强的运动控制，而这反过来又需要通过调节皮质内抑制来重新校准。
