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发育性阅读障碍的基因修饰及其在体内、体外模型中的表现

Genetic Modifications of Developmental Dyslexia and Its Representation Using In Vivo, In Vitro Model.

作者信息

Zaki Zakiyyah M M, Ali Siti A, Ghazali Mazira M, Jam Faidruz A

机构信息

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

Department of Electronic Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia.

出版信息

Glob Med Genet. 2024 Feb 27;11(1):76-85. doi: 10.1055/s-0044-1781456. eCollection 2024 Jan.

Abstract

Dyslexia is a genetic and heritable disorder that has yet to discover the treatment of it, especially at the molecular and drug intervention levels. This review provides an overview of the current findings on the environmental and genetic factors involved in developmental dyslexia. The latest techniques used in diagnosing the disease and macromolecular factors findings may contribute to a higher degree of development in detangling the proper management and treatment for dyslexic individuals. Furthermore, this review tried to put together all the models used in the current dyslexia research for references in future studies that include animal models as well as in vitro models and how the previous research has provided consistent data across many years and regions. Thus, we suggest furthering the studies using an organoid model based on the existing gene polymorphism, pathways, and neuronal function input.

摘要

阅读障碍是一种具有遗传性的疾病,目前尚未找到针对它的治疗方法,尤其是在分子和药物干预层面。这篇综述概述了目前关于发育性阅读障碍所涉及的环境和遗传因素的研究结果。用于诊断该疾病的最新技术以及大分子因素的研究结果,可能有助于更深入地理解阅读障碍患者的合理管理和治疗方法。此外,本综述试图汇总当前阅读障碍研究中使用的所有模型,以供未来研究参考,这些模型包括动物模型和体外模型,以及过去的研究如何在多年和多个地区提供了一致的数据。因此,我们建议基于现有的基因多态性、信号通路和神经元功能输入,进一步开展使用类器官模型的研究。

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本文引用的文献

1
Theories about Developmental Dyslexia.关于发育性阅读障碍的理论。
Brain Sci. 2023 Jan 26;13(2):208. doi: 10.3390/brainsci13020208.
2
Stem Cell-Based Organoid Models of Neurodevelopmental Disorders.基于干细胞的神经发育障碍类器官模型。
Biol Psychiatry. 2023 Apr 1;93(7):622-631. doi: 10.1016/j.biopsych.2023.01.012. Epub 2023 Jan 24.
3
Animal models of developmental dyslexia.发育性阅读障碍的动物模型。
Front Neurosci. 2022 Nov 14;16:981801. doi: 10.3389/fnins.2022.981801. eCollection 2022.

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