Marton I S, Jancsy G, Woloszczuk W
Exp Clin Endocrinol. 1985 Dec;86(3):361-4. doi: 10.1055/s-0029-1210510.
Since the role of gonadal steroids and their interrelation with calcium regulating hormones is not clear, we performed a prospective study to investigate the effects of gonadectomy on the calcitonin (CT)/katacalcin (KT) system using 1 minute calcium infusion as a provocative test. Seventeen women aged 26-51 years awaiting abdominal hysterectomy with bilateral oophorectomy were included in the study and the same protocol was repeated 14 days after surgery. CT and KT concentrations were determined radioimmunologically after reverse phase extraction of serum, thus predominantly measuring monomeric CT and KT. The same protocol was repeated 14 days after surgery. Removal of the gonads in reproductive age did not alter basal or peak CT levels (9.7 +/- 0.8 vs. 8.9 +/- 0.7 ng/l and 13.4 +/- 1.6 vs. 12.7 +/- 1.2 ng/l) or KT levels (3.2 +/- 1.8 vs. 3.9 +/- 2.2 ng/l basal and 4.1 +/- 2.6 vs. 5.4 +/- 2.8 ng/l peak). Although not statistically different at any individual point, the shapes of the curves were significantly altered after surgery, indicating changes in the metabolism of CT and KT. These results support the hypothesis that CT and possibly KT play a role in the change of calcium metabolism coinciding with the oestrogen withdrawal at the menopause.
由于性腺类固醇的作用及其与钙调节激素的相互关系尚不清楚，我们进行了一项前瞻性研究，以1分钟钙剂输注作为激发试验，研究性腺切除对降钙素（CT）/katacalcin（KT）系统的影响。17名年龄在26 - 51岁、等待行腹部子宫切除术加双侧卵巢切除术的女性被纳入研究，术后14天重复相同方案。血清经反相萃取后采用放射免疫法测定CT和KT浓度，从而主要检测单体CT和KT。术后14天重复相同方案。切除育龄期女性的性腺并未改变基础或峰值CT水平（分别为9.7±0.8 vs. 8.9±0.7 ng/l和13.4±1.6 vs. 12.7±1.2 ng/l）或KT水平（基础值分别为3.2±1.8 vs. 3.9±2.2 ng/l，峰值分别为4.1±2.6 vs. 5.4±2.8 ng/l）。尽管在任何单个时间点差异无统计学意义，但术后曲线形状发生了显著改变，表明CT和KT的代谢发生了变化。这些结果支持以下假设：CT以及可能的KT在绝经时雌激素撤退导致的钙代谢变化中起作用。
