Seksjon for infeksjonssjukdommar, Medisinsk klinikk, Haukeland universitetssjukehus, og, Klinisk institutt 2, Det medisinske fakultet, Universitetet i Bergen.
Avdeling for plastikk-, hand- og rekonstruktiv kirurgi, og, Brannskadeavdelinga, Haukeland universitetssjukehus, og, Klinisk institutt 1, Det medisinske fakultet, Universitetet i Bergen.
Tidsskr Nor Laegeforen. 2024 Feb 26;144(3). doi: 10.4045/tidsskr.23.0720. Print 2024 Feb 27.
Necrotising soft tissue infections can affect the skin, subcutaneous tissue, superficial fascia, deep fascia and musculature. The infections are severe, they spread quickly and can result in extensive tissue loss. Although rare, morbidity and mortality rates are high. Early clinical identification is crucial for the outcome, and rapid infection control through surgery and targeted antibiotic treatment is needed to save lives. Few prospective clinical trials have been conducted for the treatment of this type of infection. Specific challenges include rapid identification of the condition and the uncertain efficacy of the various treatment options. In this clinical review article, we describe clinical characteristics, diagnostics and treatment.
坏死性软组织感染可影响皮肤、皮下组织、浅筋膜、深筋膜和肌肉。感染严重，扩散迅速，可导致广泛的组织损失。尽管罕见，但发病率和死亡率很高。早期临床识别对预后至关重要，需要通过手术和靶向抗生素治疗迅速控制感染以挽救生命。针对这种感染的治疗方法很少进行前瞻性临床试验。具体挑战包括快速识别病情和各种治疗选择的疗效不确定。在这篇临床综述文章中，我们描述了临床特征、诊断和治疗。
