Della Giustina E, Forese S, Pace P
Pediatr Med Chir. 1985 Mar-Apr;7(2):203-13.
In this article we review the global therapy for purulent meningitis in childhood and present personal data derived from a twenty year survey study (1960 to 1980). We recommend the prompt use of adequate antibiotics at correct doses largely following the intravenous pathway in order to achieve active antimicrobial levels in the cerebrospinal fluid. On the basis of our experience we favour a more large use of either systemic chloramphenicol or intrathecal even in the neonatal period. Moreover, we think glucose infusions should be employed with great caution due to worsening of metabolism (lactate accumulation) and perfusion in the cerebral tissue.
在本文中，我们回顾了儿童化脓性脑膜炎的全球治疗方法，并展示了一项为期二十年（1960年至1980年）的调查研究所得的个人数据。我们建议迅速使用剂量正确的足量抗生素，主要采用静脉途径给药，以便在脑脊液中达到有效的抗菌水平。根据我们的经验，即使在新生儿期，我们也倾向于更多地使用全身用氯霉素或鞘内注射。此外，我们认为由于代谢恶化（乳酸堆积）和脑组织灌注问题，葡萄糖输注应极其谨慎使用。
