人补体第四成分（C4）-C末端肽的一级结构。

The primary structure of the fourth component of human complement (C4)-C-terminal peptides.

作者信息

Law S K, Gagnon J

出版信息

Biosci Rep. 1985 Oct-Nov;5(10-11):913-21. doi: 10.1007/BF01119904.

DOI:10.1007/BF01119904

Abstract

C-terminal CNBr peptides of the three polypeptide chains of C4 were obtained and sequenced. These results supplement previously obtained data, notably the protein sequence derived from cDNA sequencing of pro-C4 (Belt KT, Carroll MC & Porter RR (1984) Cell 36, 907-914) and the N-terminal sequences of the three polypeptides (Gigli I, von Zabern I & Porter RR (1977) Biochem. J. 165, 439-446), to define the complete primary structure of the plasma form of C4. The beta (656 residues), alpha (748 residues), and gamma (291 residues) chains are found in positions 1-656, 661-1408, and 1435-1725 in the pro-C4 molecule.

摘要

获得了C4三条多肽链的C末端溴化氰肽并进行了测序。这些结果补充了先前获得的数据，特别是源自前C4 cDNA测序的蛋白质序列（Belt KT、Carroll MC和Porter RR（1984年）《细胞》36卷，907 - 914页）以及三条多肽的N末端序列（Gigli I、von Zabern I和Porter RR（1977年）《生物化学杂志》165卷，439 - 446页），从而确定了血浆形式C4的完整一级结构。β链（656个残基）、α链（748个残基）和γ链（291个残基）在前C4分子中的位置分别为1 - 656、661 - 1408和1435 - 1725。