Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Genet Test Mol Biomarkers. 2024 Feb;28(2):65-69. doi: 10.1089/gtmb.2023.0676.
Long noncoding RNAs (lncRNAs) as critical molecules play an essential role in the development of cancers. In colorectal cancer (CRC), various lncRNAs are related to cell proliferation, apoptosis, migration, and invasion. prostate cancer-associated transcript 1 (), as an oncogenic factor, is a diagnostic biomarker that regulates cell proliferation, migration, invasion, and apoptosis. This study evaluated the relationship between , CRC occurrence, and pathological features of Iranian patients. The studied samples included 100 colorectal tumor tissues and 100 adjacent healthy tissues of Iranian CRC patients. RNAs were extracted from cancerous and noncancerous tissues to synthesize complementary DNA. The expression level of was assessed using the real-time PCR method, and the data analysis was assessed using SPSS software. In this study, expression level of in tumor tissue was significantly increased in Iranian patients, and pathological studies of the patients had no significant relationship with the expression profile. Our results suggested that the high expression of resulted in the occurrence of colorectal tumor tissues in Iranian patients, which can be considered a diagnostic biomarker in CRC.
长链非编码 RNA（lncRNAs）作为关键分子在癌症的发展中发挥着重要作用。在结直肠癌（CRC）中，各种 lncRNAs 与细胞增殖、凋亡、迁移和侵袭有关。前列腺癌相关转录物 1（）作为致癌因子，是一种调节细胞增殖、迁移、侵袭和凋亡的诊断生物标志物。本研究评估了 lncRNA 在伊朗患者 CRC 发生和病理特征中的关系。研究样本包括 100 例伊朗 CRC 患者的 100 例结直肠肿瘤组织和 100 例相邻健康组织。从癌组织和非癌组织中提取 RNA 以合成互补 DNA。使用实时 PCR 方法评估 的表达水平，并使用 SPSS 软件评估数据分析。在本研究中，伊朗患者肿瘤组织中 的表达水平显著升高，患者的病理研究与 的表达谱无显著关系。我们的结果表明，高表达的 导致伊朗患者结直肠肿瘤组织的发生，可作为 CRC 的诊断生物标志物。
