Alvaroliya Nazila Saedi, Jahanshahi Seyedeh Hayla, Khajehnasiri Nazli, Sehrig Fatemeh Zeinali, Abdi Adel
Department of Biological Sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
Department of Biology, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
Int J Genomics. 2025 Aug 13;2025:9917434. doi: 10.1155/ijog/9917434. eCollection 2025.
Gastric cancer (GC) is a widespread type of cancer on a global scale, standing as the fifth most frequently occurring malignant disease. Dysregulation of long noncoding RNAs (lncRNAs) due to genomic mutations in noncoding DNA sequences can contribute to the development of tumors. Detecting GC at an early stage can significantly improve the chances of survival and treatment effectiveness. The current study evaluated the expression of lncRNA in primary gastric tumors as well as in adjacent noncancerous tissues. One hundred pairs of GC and adjacent noncancerous tissue samples were acquired from Tabriz International Valiasr Hospital in Iran for the study. Subsequently, RNA extraction was conducted, and this was followed by cDNA synthesis. The expression of was evaluated using quantitative reverse transcriptase PCR (qRT-PCR). The relationship between clinicopathological characteristics and expression was analyzed using SPSS software. Furthermore, the predictive value of in GC was examined via analysis of the receiver operating characteristic (ROC) curve. exhibited a significant upregulation in tumor samples in contrast to adjacent noncancerous tissues ( < 0.0001). On the other hand, no significant relationship was detected between the elevated expression of and the clinicopathological features of the individuals ( > 0.05). The lncRNA is implicated in advancing the development of GC. Consequently, it could be considered a potential target for therapeutic interventions and a prognostic biomarker for GC patients.
胃癌（GC）是全球范围内一种广泛存在的癌症类型，是第五大最常见的恶性疾病。非编码DNA序列中的基因突变导致的长链非编码RNA（lncRNA）失调可促进肿瘤的发展。早期检测GC可显著提高生存率和治疗效果。本研究评估了lncRNA在原发性胃肿瘤以及相邻非癌组织中的表达。从伊朗大不里士国际瓦利亚斯尔医院获取了100对GC和相邻非癌组织样本用于研究。随后进行RNA提取，接着进行cDNA合成。使用定量逆转录聚合酶链反应（qRT-PCR）评估其表达。使用SPSS软件分析临床病理特征与表达之间的关系。此外，通过分析受试者工作特征（ROC）曲线来检验其在GC中的预测价值。与相邻非癌组织相比，肿瘤样本中显示出显著上调（<0.0001）。另一方面，未检测到表达升高与个体临床病理特征之间存在显著关系（>0.05）。lncRNA与GC的进展有关。因此，它可被视为治疗干预的潜在靶点和GC患者的预后生物标志物。
