The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China; Department of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China; Department of Obstetrics, The First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming 650500, China.
Environ Pollut. 2024 Apr 15;347:123611. doi: 10.1016/j.envpol.2024.123611. Epub 2024 Feb 26.
Air pollution is an environmental stimulus that may predispose pregnant women to preterm rapture of membrane (PROM). However, the relationship of maternal exposure to air pollutants and PROM is still unclear. To investigate the relationship between the long-term and short-term maternal exposure to air pollution and PROM. We searched all studies published in PubMed, Embase and Web of Science up to February 2024. The studies provided quantitative effect estimates with 95% confidence intervals, for the impact of short-term (<30 days) or long-term (≥30 days) maternal exposure to air pollutants on PROM, preterm PROM (PPROM) or term PROM (TPROM). The odds ratio (OR), risk ratio (RR), or hazard ratio (HR), with 95% confidence intervals was extracted, and RR or HR were deemed as OR because of the low prevalence of PROM. Fixed- or random-effects meta-analyses performed. In total, 17 relevant studies were included. Maternal exposure to PM in the second trimester increases the risk of PROM (pooled OR = 1.15, 95%CI: 1.05-1.26). Maternal exposure to PM, NO, NO, CO and SO during pregnancy and short-term maternal exposure to PM, NO, SO and O also associate with PROM occurrence. The results of the study show that both long-term maternal exposure in the second or third trimester and short-term maternal exposure to ambient air pollution can increase the risk of PROM.
空气污染是一种环境刺激物，可能使孕妇更容易发生胎膜早破（PROM）。然而，母体暴露于空气污染物与 PROM 的关系仍不清楚。为了研究母体长期和短期暴露于空气污染物与 PROM 的关系。我们在 PubMed、Embase 和 Web of Science 上搜索了截至 2024 年 2 月发表的所有研究。这些研究提供了定量效应估计值及其 95%置信区间，用于评估短期（<30 天）或长期（≥30 天）母体暴露于空气污染物对 PROM、早产胎膜早破（PPROM）或足月胎膜早破（TPROM）的影响。提取了比值比（OR）、风险比（RR）或风险比（HR）及其 95%置信区间，由于 PROM 的患病率较低，RR 或 HR 被视为 OR。进行了固定或随机效应荟萃分析。总共纳入了 17 项相关研究。母体在妊娠中期暴露于 PM 会增加 PROM 的风险（汇总 OR=1.15，95%CI：1.05-1.26）。母体在妊娠期间暴露于 PM、NO、NO₂、CO 和 SO₂以及短期暴露于 PM、NO、SO₂和 O 也与 PROM 的发生有关。研究结果表明，母体在妊娠第二或第三期的长期暴露以及短期暴露于环境空气污染都可能增加 PROM 的风险。
