糖尿病前期患者中锌-α-2 糖蛋白、酰化 ghrelin 和锌水平。
Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics.
机构信息
Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, Istanbul, Turkey;
Department of Biophysics, İstinye University, Faculty of Medicine, Istanbul, Turkey.
出版信息
In Vivo. 2024 Mar-Apr;38(2):975-981. doi: 10.21873/invivo.13530.
BACKGROUND/AIM: Prediabetic stages of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) exhibit differences in the sites of insulin resistance. Serum Zinc α-2 glycoprotein (ZAG), acylated ghrelin (AG), and zinc (Zn) levels can affect IFG, IGT, and diabetic glucose tolerance (DGT) differently. This study examined the importance of ZAG, AG, and serum Zn levels in prediabetic individuals with IFG, IGT, and DGT, compared to those with normal glucose levels.
PATIENTS AND METHODS
The study was conducted at İstanbul University Cerrahpaşa-Cerrahpaşa Faculty of Medicine. A total of n=151 volunteers were classified according to the WHO criteria for diabetes after undergoing an oral glucose tolerance test. Plasma and serum samples were measured by Inductively Coupled Plasma Optical Emission Spectroscopy, ELISA, and immunoassay.
RESULTS
Prediabetic conditions became more prominent with the decrease in ZAG levels. ZAG levels showed a negative correlation with acylated ghrelin and Homeostatic Model Assessment for assessing beta-cell function and insulin resistance. Zinc levels were significantly lower in DGT.
CONCLUSION
ZAG levels have regulatory effects on insulin resistance and plasma glucose levels are mediated by zinc and acylated ghrelin.
背景/目的：空腹血糖受损（IFG）和葡萄糖耐量受损（IGT）的糖尿病前期阶段在胰岛素抵抗部位存在差异。血清锌α-2 糖蛋白（ZAG）、酰化胃饥饿素（AG）和锌（Zn）水平可能对 IFG、IGT 和糖尿病葡萄糖耐量（DGT）产生不同的影响。本研究比较了 IFG、IGT 和 DGT 与正常血糖水平的糖尿病前期个体，研究了 ZAG、AG 和血清 Zn 水平在其中的重要性。
患者和方法
该研究在伊斯坦布尔大学 Cerrahpaşa-Cerrahpaşa 医学院进行。共有 n=151 名志愿者在口服葡萄糖耐量试验后根据世界卫生组织的糖尿病标准进行分类。通过电感耦合等离子体光发射光谱法、酶联免疫吸附试验和免疫测定法测量血浆和血清样本。
结果
随着 ZAG 水平的降低，糖尿病前期状态变得更加明显。ZAG 水平与酰化胃饥饿素和稳态模型评估β细胞功能和胰岛素抵抗呈负相关。DGT 中的锌水平显著降低。
结论
ZAG 水平对胰岛素抵抗具有调节作用，而血浆葡萄糖水平则由锌和酰化胃饥饿素介导。
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