与空腹服用锌相比，随餐服用锌补充剂可提高成年男性必需脂肪酸去饱和指数。

Zinc Supplements Taken with Food Increase Essential Fatty Acid Desaturation Indices in Adult Men Compared with Zinc Taken in the Fasted State.

机构信息

Children's Hospital Oakland Research Institute, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA.

Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, USA.

出版信息

J Nutr. 2021 Sep 4;151(9):2583-2589. doi: 10.1093/jn/nxab149.

DOI:10.1093/jn/nxab149

PMID:34236435

Abstract

BACKGROUND

Zinc intake is associated with reduced risk of metabolic disease in adults, possibly due in part to zinc's role in essential fatty acid (EFA) desaturation. Although plasma zinc is the accepted indicator of zinc status, product-to-precursor activity indices of fatty acid desaturase (FADS) 1 and 2 have also been proposed as response indicators for changes in zinc intake.

OBJECTIVES

To examine zinc supplement effects on plasma zinc concentration (PZC) and estimated FADS 1 and 2 activities, when zinc supplements are taken with food compared with fasted.

METHODS

Apparently healthy adult men were randomly allocated to take 25 mg zinc as zinc gluconate either in the fasted state 30 min before breakfast [zinc before breakfast (ZBB)] or with breakfast [zinc with breakfast (ZWB)] daily for 13 d. Fasting PZC was measured by inductively coupled plasma optical emission spectrometry. Selected EFAs for FADS activity indices were measured by LC-MS/MS at study baseline and end.

RESULTS

A total of 35 men completed the study (ZBB, n = 18; ZWB, n = 17). Mean ± SEM PZC was 86.2 ± 1.64 μg/dL at baseline. After 2 wk of zinc supplementation, the PZCs were 18% higher in the ZBB compared with the ZWB groups (105 ± 5.88 compared with 88.7 ± 2.36 μg/dL, P = < 0.05). However, the geometric mean (95% CI) FADS1 activity indices were 15% higher in the ZWB than the ZBB participants, 6.45 (5.84, 7.13) compared with 5.57 (5.05, 6.14), P < 0.05.

CONCLUSIONS

These data demonstrate a lack of congruence between the effects of zinc supplements on PZC and EFA metabolism in response to whether a zinc supplement is taken with or without food. Additional research is needed to determine how absorbed zinc may be directed differently toward metabolic processes, when coabsorbed with food. This trial was registered at clinicaltrials.gov as NCT03619421.

摘要

背景

锌的摄入与成年人代谢疾病风险的降低有关，这可能部分归因于锌在必需脂肪酸（EFA）去饱和中的作用。尽管血浆锌是锌状态的公认指标，但脂肪酸去饱和酶（FADS）1 和 2 的产物-前体活性指数也被提议作为锌摄入量变化的反应指标。

目的

当锌补充剂与食物一起服用与空腹相比时，检查锌补充剂对血浆锌浓度（PZC）和估计的 FADS1 和 2 活性的影响。

方法

将 35 名健康成年男性随机分配，每天分别空腹 30 分钟前早餐时服用 25mg 葡萄糖酸锌（锌早餐前（ZBB））或与早餐一起服用（ZWB）[锌早餐后（ZBB）]，持续 13 天。通过电感耦合等离子体发射光谱法测量空腹 PZC。在研究基线和结束时，通过 LC-MS/MS 测量用于 FADS 活性指数的选定必需脂肪酸。

结果

共有 35 名男性完成了这项研究（ZBB，n=18；ZWB，n=17）。基线时平均±SEM PZC 为 86.2±1.64μg/dL。在锌补充 2 周后，ZBB 组的 PZC 比 ZWB 组高 18%（105±5.88 与 88.7±2.36μg/dL，P<0.05）。然而，ZWB 组的 FADS1 活性指数的几何平均值（95%CI）比 ZBB 组高 15%，6.45（5.84，7.13）与 5.57（5.05，6.14），P<0.05。