Jarman Molly P, Jin Ginger, Chen Annie, Losina Elena, Weissman Joel S, Berry Sarah D, Salim Ali
Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
J Am Geriatr Soc. 2024 May;72(5):1384-1395. doi: 10.1111/jgs.18830. Epub 2024 Feb 28.
Opioids are recommended for pain management in patients being cared for and transported by emergency medical services, but no specific guidelines exist for older adults with fall-related injury. Prior research suggests prehospital opioid administration can effectively manage pain in older adults, but less is known about safety in this population. We compared short-term safety outcomes, including delirium, disposition, and length of stay, among older adults with fall-related injury according to whether they received prehospital opioid analgesia.
We linked Medicare claims data with prehospital patient care reports for older adults (≥65) with fall-related injury in Illinois between January 1, 2014 and December 31, 2015. We used weighted regression models (logistic, multinomial logistic, and Poisson) to assess the association between prehospital opioid analgesia and incidence of inpatient delirium, hospital disposition, and length of stay.
Of 28,150 included older adults, 3% received prehospital opioids. Patients receiving prehospital opioids (vs. no prehospital opioids) were less likely to be discharged home from the emergency department (adjusted probability = 0.30 [95% CI: 0.25, 0.34] vs. 0.47 [95% CI: 0.46, 0.48]), more likely to be discharged to a non-home setting after an inpatient admission (adjusted probability = 0.43 [95% CI: 0.39, 0.48] vs. 0.30 [95% CI: 0.30, 0.31]), had inpatient length of stay 0.4 days shorter (p < 0.001) and ICU length of stay 0.7 days shorter (p = 0.045). Incidence of delirium did not vary between treatment and control groups.
Few older adults receive opioid analgesia in the prehospital setting. Prehospital opioid analgesia may be associated with hospital disposition and length of stay for older adults with fall-related injury. However, our findings do not provide evidence of an association with inpatient delirium. These findings should be considered when developing guidelines for prehospital pain management specific to the older adult population.
阿片类药物被推荐用于接受紧急医疗服务护理和转运患者的疼痛管理,但对于因跌倒受伤的老年人尚无具体指南。先前的研究表明,院前给予阿片类药物可有效管理老年人的疼痛,但对于该人群的安全性了解较少。我们比较了因跌倒受伤的老年人接受院前阿片类镇痛与未接受院前阿片类镇痛的短期安全结局,包括谵妄、出院情况和住院时间。
我们将2014年1月1日至2015年12月31日期间伊利诺伊州因跌倒受伤的老年人(≥65岁)的医疗保险理赔数据与院前患者护理报告相链接。我们使用加权回归模型(逻辑回归、多项逻辑回归和泊松回归)来评估院前阿片类镇痛与住院谵妄发生率、医院出院情况和住院时间之间的关联。
在纳入的28150名老年人中,3%接受了院前阿片类药物治疗。接受院前阿片类药物治疗的患者(与未接受院前阿片类药物治疗的患者相比)从急诊科出院回家的可能性较小(调整后概率 = 0.30 [95% CI:0.25, 0.34] 对 0.47 [95% CI:0.46, 0.48]),住院后出院到非家庭环境的可能性更大(调整后概率 = 0.43 [95% CI:0.39, 0.48] 对 0.30 [95% CI:0.30, 0.31]),住院时间短0.4天(p < 0.001),重症监护病房住院时间短0.7天(p = 0.045)。谵妄发生率在治疗组和对照组之间没有差异。
很少有老年人在院前环境中接受阿片类镇痛治疗。院前阿片类镇痛可能与因跌倒受伤的老年人的医院出院情况和住院时间有关。然而,我们的研究结果并未提供与住院谵妄相关的证据。在制定针对老年人群的院前疼痛管理指南时应考虑这些发现。