Matsunaga Masaaki, He Yupeng, Khine May Thet, Shi Xuliang, Okegawa Ryusei, Li Yuanying, Yatsuya Hiroshi, Ota Atsuhiko
Department of Public Health, Fujita Health University School of Medicine, Toyoake, 470-1192, Japan.
Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Nagoya, 466-8550, Japan.
J Cancer Surviv. 2024 Feb 28. doi: 10.1007/s11764-024-01557-8.
The aim of this study is to evaluate the prevalence, severity, and risk factors of cancer-related fatigue among currently working cancer survivors.
We searched the PubMed, Embase, Scopus, CINAHL, Cochrane Library, and ICHUSHI databases. The risk of bias was evaluated independently using the Risk of Bias Assessment Tool for Non-randomized Studies (RoBANS). A meta-analysis was conducted to determine the prevalence, severity, and related factors associated with cancer-related fatigue among currently working cancer survivors.
Our meta-analysis included 18 studies and revealed that 42.2% of currently working cancer survivors experience cancer-related fatigue. The fatigue severity in this group was significantly higher than that in workers without cancer (absolute standardized mean difference (SMD) = 0.67), but lower than that in cancer survivors who had previously worked and were not currently working (absolute SMD = 0.72). Distress was identified as a potential risk factor for cancer-related fatigue in working cancer survivors (partial correlation coefficient = 0.38).
The high prevalence of cancer-related fatigue among employed cancer survivors underscores the need for targeted workplace interventions and fatigue management strategies. While the severity of fatigue is less than that seen in non-working survivors, the comparison with the general working population highlights a significant health disparity. The association between distress and fatigue suggests the necessity for a holistic approach to fatigue management that considers both physical and mental factors in working cancer survivors.
Our findings highlight the critical need for healthcare professionals and employers to monitor fatigue levels among working cancer survivors and offer appropriate support.
本研究旨在评估目前仍在工作的癌症幸存者中与癌症相关疲劳的患病率、严重程度及风险因素。
我们检索了PubMed、Embase、Scopus、CINAHL、Cochrane图书馆和日本医学中央杂志数据库。使用非随机研究偏倚风险评估工具（RoBANS）独立评估偏倚风险。进行荟萃分析以确定目前仍在工作的癌症幸存者中与癌症相关疲劳的患病率、严重程度及相关因素。
我们的荟萃分析纳入了18项研究，结果显示42.2%目前仍在工作的癌症幸存者经历与癌症相关的疲劳。该组的疲劳严重程度显著高于无癌症的工作者（绝对标准化均数差（SMD）=0.67），但低于既往工作但目前已不工作的癌症幸存者（绝对SMD=0.72）。痛苦被确定为在职癌症幸存者中与癌症相关疲劳的潜在风险因素（偏相关系数=0.38）。
在职癌症幸存者中与癌症相关疲劳的高患病率凸显了针对性的工作场所干预措施和疲劳管理策略的必要性。虽然疲劳严重程度低于未工作的幸存者，但与一般在职人群相比仍存在显著的健康差距。痛苦与疲劳之间的关联表明，有必要采取综合方法来管理疲劳，同时考虑在职癌症幸存者的身体和心理因素。
我们的研究结果凸显了医疗保健专业人员和雇主监测在职癌症幸存者疲劳水平并提供适当支持的迫切需求。
