Department of Neurorehabilitation Medicine, Rijndam Rehabilitation, Rotterdam, The Netherlands. E-mail:
J Rehabil Med. 2021 May 28;53(5):jrm00198. doi: 10.2340/16501977-2837.
To investigate employment status and return to work in relation to fatigue in patients with World Health Organization (WHO) grade II glioma.
Exploratory cross-sectional study.
Patients with grade II glioma, who underwent surgery between 2005 and 2016.
A postal survey was sent in 2019, which included the Short Form-Health and Labour Questionnaire and the Multi-dimensional Fatigue Index. Outcomes of fatigue in subgroups of (not-)return to work were compared using independent t-tests and χ2 tests. The association between fatigue and return to work was analysed using multivariable logistic regression.
In total, 73 patients were included in the study (age at diagnosis 41.0 years (standard deviation (SD) 9.2 years), time post-diagnosis 8.0 years (interquartile range (IQR) 6-11 years). At diagnosis, 61 patients were employed and 32 returned to work during follow-up. The return to work group was significantly younger than the not-return to work group (p = 0.007). The proportion of patients who indicated that the consequences of glioma had affected return to work, in terms of demotion or reduced working hours, was 68.7%. The not-return to work group reported significantly more fatigue in all domains than the return to work group (p < 0.05). Mental fatigue (p = 0.023) and physical fatigue (p = 0.065) were independently associated with return to work, adjusted for age, sex and the use of anti-epileptic drugs.
Long-term fatigue is associated with return to work in patients with grade II glioma. Patients who were able to work in the long term were less fatigued, younger, more often male, and used less anti-epileptic drugs than the patients who did not return to work.
研究与疲劳相关的世界卫生组织（WHO）Ⅱ级胶质瘤患者的就业状况和重返工作岗位情况。
探索性横断面研究。
2005 年至 2016 年间接受手术治疗的Ⅱ级胶质瘤患者。
2019 年进行了一项邮寄调查，其中包括健康和劳动简表以及多维疲劳指数。使用独立 t 检验和 χ2 检验比较（未）重返工作的亚组中疲劳的结果。使用多变量逻辑回归分析疲劳与重返工作的关系。
共纳入 73 例患者（诊断时年龄为 41.0 岁（标准差 9.2 岁），诊断后时间为 8.0 年（四分位距 6-11 年）。在诊断时，61 例患者有工作，32 例在随访期间重返工作。重返工作组明显比未重返工作组年轻（p=0.007）。因胶质瘤而影响重返工作，包括降职或减少工作时间的患者比例为 68.7%。未重返工作组在所有领域的疲劳感均明显高于重返工作组（p<0.05）。调整年龄、性别和使用抗癫痫药物后，精神疲劳（p=0.023）和身体疲劳（p=0.065）与重返工作独立相关。
长期疲劳与Ⅱ级胶质瘤患者重返工作岗位相关。能够长期工作的患者疲劳程度较低，年龄较小，男性较多，使用的抗癫痫药物较少。
