School of Public Health, Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, Shandong, China.
Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
Respir Res. 2024 Feb 28;25(1):105. doi: 10.1186/s12931-024-02679-4.
Increasing evidence is appearing that ozone has adverse effects on health. However, the association between long-term ozone exposure and lung function is still inconclusive.
To investigate the associations between long-term exposure to ozone and lung function in Chinese young adults.
We conducted a prospective cohort study among 1594 college students with a mean age of 19.2 years at baseline in Shandong, China from September 2020 to September 2021. Lung function indicators were measured in September 2020 and September 2021, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), forced expiratory flow at the 25th, 50th, and 75th percentile of the FVC (FEF25, FEF50, and FEF75) and mean flow rate between 25% and 75% of the FVC (FEF25-75) were measured. Daily 10 km×10 km ozone concentrations come from a well-validated data-fusion approach. The time-weighted average concentrations in 12 months before the lung function test were defined as the long-term ozone exposure. The associations between long-term ozone exposure and lung function indicators in Chinese young adults were investigated using a linear mixed effects model, followed by stratified analyses regarding sex, BMI and history of respiratory diseases.
Each interquartile range (IQR) (8.9 µg/m) increase in long-term ozone exposure were associated with a -204.3 (95% confidence interval (CI): -361.6, -47.0) ml/s, -146.3 (95% CI: -264.1, -28.4) ml/s, and - 132.8 (95% CI: -239.2, -26.4) ml/s change in FEF25, FEF50, and FEF25-75, respectively. Stronger adverse associations were found in female participants or those with BMI ≥ 24 kg/m and history of respiratory diseases.
Long-term exposure to ambient ozone is associated with impaired small airway indicators in Chinese young adults. Females, participants with BMI ≥ 24 kg/m and a history of respiratory disease have stronger associations.
越来越多的证据表明臭氧对健康有不良影响。然而，长期暴露于臭氧与肺功能之间的关系仍不确定。
探讨中国年轻成年人长期暴露于臭氧与肺功能之间的关系。
我们在中国山东进行了一项前瞻性队列研究，纳入了 1594 名平均年龄为 19.2 岁的大学生，基线调查时间为 2020 年 9 月至 2021 年 9 月。在 2020 年 9 月和 2021 年 9 月测量了肺功能指标，包括用力肺活量（FVC）、1 秒用力呼气量（FEV1）、FVC 第 25、50 和 75 百分位的用力呼气流量（FEF25、FEF50 和 FEF75）以及 FVC 之间 25%至 75%的平均流量（FEF25-75）。每日 10km×10km 臭氧浓度来自经过良好验证的数据融合方法。肺功能测试前 12 个月的时间加权平均浓度定义为长期臭氧暴露。采用线性混合效应模型研究中国年轻成年人长期臭氧暴露与肺功能指标之间的关系，然后根据性别、BMI 和呼吸系统疾病史进行分层分析。
长期臭氧暴露每增加一个四分位距（IQR）（8.9μg/m），FEF25、FEF50 和 FEF25-75 分别降低 204.3（95%置信区间（CI）：-361.6，-47.0）ml/s、146.3（95% CI：-264.1，-28.4）ml/s 和-132.8（95% CI：-239.2，-26.4）ml/s。在女性参与者或 BMI≥24kg/m 和有呼吸系统疾病史的参与者中，发现了更强的不良关联。
长期暴露于环境臭氧与中国年轻成年人小气道指标受损有关。女性、BMI≥24kg/m 和有呼吸系统疾病史的参与者关联更强。
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