Prevalence of IgM and IgG positive cats in Los Angeles County, California.

OBJECTIVES

The objective of this study was to determine the prevalence of IgM and IgG positive cats in Los Angeles County, California. antibodies are common in sera from cats in most reported studies around the world. Although the majority of infected cats never develop clinical disease, development of acute infection and recrudescence of latent infection secondary to immunosuppression has been reported. Knowledge of the serologic status of may be important when considering immunosuppressive treatments.

METHODS

IgM and IgG antibody titers were measured in 225 cats. Sera from owned cats tested at a multispecialty veterinary hospital were included both retrospectively and prospectively (n = 125). Sera from feral cats tested through a collaborating humane society were included prospectively (n = 100).

RESULTS

Of the 13 (5.8%) cats with IgM titers, 10 were positive at the minimal cut-off titer (1:64), one cat was clinically ill and none were currently positive for IgG antibodies, suggesting false-positive results for nine cats, giving an adjusted IgM prevalence rate of 1.8% (95% CI 0.7-4.5). A total of five (2.2%) cats were positive for IgG antibodies and no cat was positive for both antibodies.

CONCLUSIONS AND RELEVANCE

Most studies of antibodies in cat sera from California have shown higher prevalence rates, suggesting the cats in this municipality have a low risk of exposure. The study emphasizes that serological test results do not necessarily correlate to the presence of clinical illness.