Lappin M R, Cayatte S, Powell C C, Gigliotti A, Cooper C, Roberts S M
Department of Clinical Sciences, College Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Am J Vet Res. 1993 Mar;54(3):415-9.
Enzyme-linked immunosorbent assays for the detection of Toxoplasma gondii antigen-containing IgM immune complexes (T gondii-specific IgM-IC) and IgG immune complexes (T gondii-specific IgG-IC) in the serum of cats were developed. Serum from clinically ill, naturally infected cats; healthy, naturally infected cats; and healthy cats experimentally inoculated with T gondii was assayed. All combinations of T gondii-specific IgM, IgG, antigens, IgM-IC, and IgG-IC were detected in naturally infected and experimentally infected cats. Clinically ill cats and cats with ocular signs of toxoplasmosis were more likely than healthy cats to have T gondii-specific IC in serum. It was concluded that T gondii-specific IC form in the serum of cats, may play a role in clinical disease development, and affect the results of T gondii-specific IgM, IgG, and antigen serologic assays.
已开发出用于检测猫血清中含弓形虫抗原的IgM免疫复合物（弓形虫特异性IgM-IC）和IgG免疫复合物（弓形虫特异性IgG-IC）的酶联免疫吸附测定法。对临床患病的自然感染猫、健康的自然感染猫以及经实验接种弓形虫的健康猫的血清进行了检测。在自然感染和实验感染的猫中均检测到了弓形虫特异性IgM、IgG、抗原、IgM-IC和IgG-IC的所有组合。临床患病猫和有弓形虫病眼部症状的猫比健康猫更有可能在血清中出现弓形虫特异性免疫复合物。得出的结论是，弓形虫特异性免疫复合物在猫血清中形成，可能在临床疾病发展中起作用，并影响弓形虫特异性IgM、IgG和抗原血清学检测结果。
