Shubbar Qamar, Alchakee Aminah, Issa Khaled Walid, Adi Abdul Jabbar, Shorbagi Ali Ibrahim, Saber-Ayad Maha
College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Front Pharmacol. 2024 Feb 14;15:1326776. doi: 10.3389/fphar.2024.1326776. eCollection 2024.
The gene is frequently included in different pharmacogenomic panels tested in clinical practice, due to its involvement in the metabolism of a myriad of frequently prescribed medications. Accordingly, genotyping can promote precise therapeutic decisions and avoid the occurrence of significant drug-drug-gene interactions in the clinical setting. A comprehensive examination of the role of the gene in real-world medical settings is presented in this review. This review summarizes the most recent information on how genetic variants in affect drug metabolism and therapeutic outcomes. It goes into the wide range of CYP2C19 phenotypes, with different degrees of metabolizing activity, and their implications for customized medication response through a review of the literature. The review also analyzes the clinical significance of in several medical specialties, including cardiology, psychiatry, and gastro-enterology clinics, and illuminates how it affects pharmacological efficacy, safety, and adverse effects. Finally, -supported clinical decision-making is outlined, highlighting the possibility of improving therapeutic outcomes and achieving more affordable treatment options, a step towards optimizing healthcare provision through precision medicine.
由于该基因参与了众多常用处方药的代谢，因此在临床实践中，它经常被纳入不同的药物基因组检测面板。相应地，基因分型可以促进精确的治疗决策，并避免在临床环境中发生重大的药物-药物-基因相互作用。本综述对该基因在实际医疗环境中的作用进行了全面研究。本综述总结了关于该基因中的遗传变异如何影响药物代谢和治疗结果的最新信息。通过文献综述，它探讨了具有不同代谢活性程度的广泛的CYP2C19表型，以及它们对定制药物反应的影响。该综述还分析了该基因在包括心脏病学、精神病学和胃肠病学诊所在内的几个医学专科中的临床意义，并阐明了它如何影响药理疗效、安全性和不良反应。最后，概述了基于该基因的临床决策，强调了改善治疗结果和实现更经济实惠的治疗选择的可能性，这是朝着通过精准医学优化医疗保健服务迈出的一步。
