Institute of Anatomy and Clinical Morphology, University Witten/Herdecke, Witten, Germany.
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Knappschaftskrankenhaus Bochum and Ruhr University Bochum, Bochum, Germany.
PLoS One. 2024 Feb 29;19(2):e0299320. doi: 10.1371/journal.pone.0299320. eCollection 2024.
This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine is a new so-called bias opioid that is approved for severe pain requiring an opioid. Due to its biased agonism, it is said to have fewer side effects than conventional opioids. This systematic review and meta-analysis will analyze the efficacy, safety, and side effects of oliceridine compared to placebo or morphine in acute postoperative pain for up to 72 hours. In January 2024, an extensive search in various databases will be performed without restrictions for randomized controlled trials with at least single blinding. After data extraction, data will be pooled and meta-analytic calculations performed. A random-effects model will be used. Dichotomous data will be presented as risk ratio and continuous data as standardized mean difference. Dose-dependent side effects will be evaluated with meta-regression. Heterogeneity will be assessed via the Q statistic and prediction interval in case of a sufficient number of included studies. Publication bias will be examined using funnel plot and Duval and Tweedie's trim and fill method.
这将是第一篇关于奥利塞定在术后疼痛中的疗效、安全性和副作用的荟萃分析。我们的目的是在广泛的术后背景下评估这种相对较新的物质的临床实用性。奥利塞定是一种新的所谓偏向阿片类药物，已被批准用于需要阿片类药物的严重疼痛。由于其偏向激动作用，据称它比传统阿片类药物的副作用更少。这项系统评价和荟萃分析将分析奥利塞定与安慰剂或吗啡在急性术后疼痛中的疗效、安全性和副作用，时间长达 72 小时。2024 年 1 月，将在各种数据库中进行广泛搜索，不受限制地纳入至少有单盲的随机对照试验。在提取数据后，将对数据进行汇总并进行荟萃分析计算。将使用随机效应模型。二项数据将表示为风险比，连续数据将表示为标准化均数差。将使用元回归评估剂量依赖性副作用。如果纳入的研究数量足够，将通过 Q 统计量和预测区间评估异质性。将使用漏斗图和 Duval 和 Tweedie 的修剪和填充方法检查发表偏倚。
