Narayanan Deepika, Rogge Megan
From the Department of Dermatology, John P. and Kathrine G. McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.
Dermatitis. 2024 Sep-Oct;35(5):431-442. doi: 10.1089/derm.2023.0276. Epub 2024 Feb 29.
Cheilitis, or inflammation of the lips, is a common reason for dermatologic consultation. The inflammation can include the vermillion lip, vermillion border, and surrounding skin, and can present with an acute or chronic course. There are many etiologies, including irritant and allergic contact dermatitis, atopic cheilitis, actinic cheilitis, infectious etiologies, nutritional deficiencies, drug-induced cheilitis, and rare etiologies, including granulomatous cheilitis, cheilitis glandularis, plasma cell cheilitis, lupus cheilitis, and exfoliative cheilitis. Distinguishing among the various etiologies of cheilitis is clinically difficult, as many causes may produce similar erythema and superficial desquamation of mucosal skin. In addition, patients report dryness, redness, irritation, burning, fissuring, and itch in many of the underlying causes. Thus, the specific etiology of cheilitis is often difficult to diagnose, requiring extensive testing and treatment trials. In this review, we summarize the various types of cheilitis, synthesizing novel cases, clinical presentations, histopathology, epidemiology, and advancements in diagnostic methods and therapeutics. We provide a diagnostic algorithm aimed to assist clinicians in the management of cheilitis.
唇炎，即唇部炎症，是皮肤科会诊的常见原因。炎症可累及唇红、唇红缘及周围皮肤，病程可为急性或慢性。其病因众多，包括刺激性和过敏性接触性皮炎、特应性唇炎、光化性唇炎、感染性病因、营养缺乏、药物性唇炎以及罕见病因，如肉芽肿性唇炎、腺性唇炎、浆细胞性唇炎、狼疮性唇炎和剥脱性唇炎。区分唇炎的各种病因在临床上颇具难度，因为许多病因可能导致类似的黏膜皮肤红斑和浅表脱屑。此外，患者在许多潜在病因中都会出现干燥、发红、刺激、灼痛、皲裂和瘙痒等症状。因此，唇炎的具体病因往往难以诊断，需要进行广泛的检查和治疗试验。在本综述中，我们总结了各种类型的唇炎，综合了新病例、临床表现、组织病理学、流行病学以及诊断方法和治疗方面的进展。我们提供了一种诊断算法，旨在协助临床医生管理唇炎。
