Lehnert S, Rybka W B
Br J Radiol. 1985 Aug;58(692):745-9. doi: 10.1259/0007-1285-58-692-745.
The dose-rate dependence of lung damage in mice has been studied using LD50/50-180 as an index of the incidence of radiation pneumonitis. Mean lethal doses for 60Co gamma radiation to the thorax delivered at 100, 25 and 6 cGy/min were 1403, 1923 and 2488 cGy respectively. There were statistically significant differences between values obtained at 6 and 25 cGy/min and between those obtained at 25 and 100 cGy/min. An isoeffect plot of this data on a log-log graph shows the sparing effect of dose rate reduction to be greater for the lung than for more rapidly responding systems (colony forming units of small intestine and Chinese hamster cells in culture).
以LD50/50 - 180作为放射性肺炎发病率指标，研究了小鼠肺部损伤的剂量率依赖性。以100、25和6 cGy/分钟的剂量率对胸部进行60Coγ射线照射时，平均致死剂量分别为1403、1923和2488 cGy。6和25 cGy/分钟时获得的值之间以及25和100 cGy/分钟时获得的值之间存在统计学显著差异。在对数-对数图上绘制该数据的等效应曲线表明，与反应更快的系统（小肠集落形成单位和培养中的中国仓鼠细胞）相比，降低剂量率对肺部的保护作用更大。
