Howell M J, Dawson P
Br J Radiol. 1985 Sep;58(693):845-8. doi: 10.1259/0007-1285-58-693-845.
The inhibition of enzymes by radiological contrast agents has been invoked to explain some of their clinical effects. In a previous paper, in-vitro studies of the inhibition of the enzyme acetylcholinesterase were presented and some clinical correlations were discussed. More detailed studies, described here, have now shed new light on the mechanisms involved in this important phenomenon. Because the findings restore the iodine atoms to a central role, they have important general implications for contrast agent pharmacology.
放射造影剂对酶的抑制作用已被用来解释其一些临床效应。在之前的一篇论文中，展示了对乙酰胆碱酯酶抑制作用的体外研究，并讨论了一些临床相关性。本文所述的更详细研究，现在对这一重要现象所涉及的机制有了新的认识。由于这些发现使碘原子重新发挥核心作用，它们对造影剂药理学具有重要的普遍意义。
