Fillette F, Nassif G
Salpêtrière Hospital, Department of Cardiology, Paris, France.
Can J Cardiol. 1987 Nov;3 Suppl A:11A-15A.
The effect of two low osmolar contrast media (sodium ioxitalamate and sodium ioxaglate) and two nonionic media (iohexol and iopamidol) on cellular electrophysiological properties of sheep myocardium and Purkinje fibres was studied at two concentrations of each medium. Neither sodium ioxitalamate nor ioxaglate had significant effects on any of the parameters measured. Iohexol (10 mL/L) caused a loss of resting potential, a decrease in action potential and duration, and a decrease in refractory period of the myocardium. No change in Purkinje fibres was observed. Iopamidol induced an increase in relative refractory period in both myocardium and Purkinje fibres at 1 mL/L and had a significant effect on all parameters studied at 10 mL/L. Automaticity was not observed after perfusion with any agent at either concentration.
研究了两种低渗造影剂（碘他拉酸钠和碘克沙酸钠）以及两种非离子型造影剂（碘海醇和碘帕醇）在两种浓度下对绵羊心肌和浦肯野纤维细胞电生理特性的影响。碘他拉酸钠和碘克沙酸钠对所测的任何参数均无显著影响。碘海醇（10 mL/L）导致静息电位丧失、动作电位和时程降低以及心肌不应期缩短。在浦肯野纤维中未观察到变化。碘帕醇在1 mL/L时使心肌和浦肯野纤维的相对不应期均增加，在10 mL/L时对所有研究参数均有显著影响。在任一浓度下用任何一种试剂灌注后均未观察到自律性。
