镉对哺乳动物卵母细胞染色体的诱变作用。

Mutagenic effects of cadmium on mammalian oocyte chromosomes.

作者信息

Watanabe T, Shimada T, Endo A

出版信息

Mutat Res. 1979 Aug;67(4):349-56. doi: 10.1016/0165-1218(79)90031-4.

Abstract

When female golden hamsters were treated with cadmium chloride at the oogenesis stages of diakinesis/metaphase I to metaphase II, oocytes with the chromosomal complements of hyperhaploidy and diploidy, as well as oocytes at the anaphase-I stage, were observed. Oocytes of this species were especially sensitive to cadmium. Chromosome analysis of metaphase-II oocytes seems to be a useful method for the screening of mutagenicity of environmental contaminants in mammalian germ cells in vivo.

摘要

当雌性金黄仓鼠在减数分裂终变期/中期I至中期II的卵子发生阶段用氯化镉处理时，观察到具有超单倍体和二倍体染色体组成的卵母细胞，以及处于后期I阶段的卵母细胞。该物种的卵母细胞对镉特别敏感。中期II卵母细胞的染色体分析似乎是一种筛选体内哺乳动物生殖细胞中环境污染物致突变性的有用方法。