Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via Pace, 9, Milan 20122, Italy; Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy.
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy.
Dermatol Clin. 2024 Apr;42(2):247-265. doi: 10.1016/j.det.2023.12.004. Epub 2024 Jan 4.
Hidradenitis suppurativa (HS) is an autoinflammatory skin disorder of the terminal hair follicle, which can present in sporadic, familial, or syndromic form. A classification has been proposed for the latter, distinguishing cases associated with a known genetic condition, with follicular keratinization disorders or with autoinflammatory diseases. This review focuses on the clinical and genetic features of those entities (ie, pyoderma gangrenosum [PG], acne and HS; PG, acne, pyogenic arthritis and HS; psoriatic arthritis, PG, acne and HS; synovitis, acne, pustulosis, hyperostosis, osteitis; and so forth) for which the collective term HS-related autoinflammatory syndromes is proposed.
化脓性汗腺炎（HS）是一种毛囊末端的自身炎症性皮肤病，可表现为散发性、家族性或综合征性。目前已经提出了一种分类方法，将其分为与已知遗传疾病相关、与毛囊角化障碍相关或与自身炎症性疾病相关的病例。本综述重点介绍了这些疾病（即坏疽性脓皮病[PG]、痤疮和 HS；PG、痤疮、化脓性关节炎和 HS；银屑病关节炎、PG、痤疮和 HS；滑膜炎、痤疮、脓疱病、骨质增生、骨炎；等等）的临床和遗传特征，对于这些疾病，提出了 HS 相关自身炎症性综合征的统称。
