Nirmal Kumar A, Kalyankar G D
Indian J Physiol Pharmacol. 1985 Oct-Dec;29(4):207-12.
Experiments have been carried out on liver and Kidneys to study the age dependent changes in alanine and aspartate aminotransferases and the influence of steroid hormones corticosterone (catabolic), testosterone (anabolic) and vitamin B6 on these changes. The rats used were of the ages between 7 to 73 weeks. It is observed that specific activity of alanine aminotransferase as well as the activity per liver increased with age. The same is true with the kidneys. Corticosterone treatment brings about two and half fold increase in activity in the liver of younger rats, whereas there is only 25% increase in the oldest group. Testosterone and vitamin B6 lower this activity, the latter showed more pronounced effect. In the case of kidneys the changes are marginal. Aspartate aminotransferase shows marginal changes in the specific activities in both liver and kidney, whereas the total activity increases with age, except in the case of liver where there is decrease at 73 weeks. Both testosterone and vitamin B6 have marginal influence on the kidney enzyme. There is no apparent explanation for the differential behaviour of the two enzymes.
已对肝脏和肾脏进行实验，以研究丙氨酸转氨酶和天冬氨酸转氨酶随年龄的变化，以及类固醇激素皮质酮（分解代谢）、睾酮（合成代谢）和维生素B6对这些变化的影响。所用大鼠年龄在7至73周之间。观察到丙氨酸转氨酶的比活性以及每克肝脏的活性均随年龄增加。肾脏情况相同。皮质酮处理使年轻大鼠肝脏中的活性增加了两倍半，而最年长组仅增加了25%。睾酮和维生素B6降低了这种活性，后者的作用更为明显。在肾脏中，变化很小。天冬氨酸转氨酶在肝脏和肾脏中的比活性变化很小，而总活性随年龄增加，肝脏除外，在73周时有所下降。睾酮和维生素B6对肾脏酶的影响都很小。对于这两种酶的不同表现，尚无明显解释。
