儿童和青少年新冠后综合征的病理生理学、临床表现及管理综述
A review of post COVID syndrome pathophysiology, clinical presentation and management in children and young people.
作者信息
Johnston Rebecca, Sonnappa Samatha, Goddings Anne-Lise, Whittaker Elizabeth, Segal Terry Y
机构信息
Paediatric and Adolescent Division, University College London Hospitals NHS Foundation Trust, London, UK.
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.
出版信息
Paediatr Respir Rev. 2025 Mar;53:14-22. doi: 10.1016/j.prrv.2024.01.002. Epub 2024 Jan 18.
Post Covid Syndrome (PCS) is a complex multi-system disorder with a spectrum of presentations. Severity ranges from mild to very severe with variable duration of illness and recovery. This paper discusses the difficulties defining and describing PCS. We review the current understanding of PCS, epidemiology, and predisposing factors. We consider potential mechanisms including viral persistence, clotting dysfunction and immunity. We review presentation and diagnosis and finally consider management strategies including addressing symptom burden, rehabilitation, and novel therapies.
新冠后综合征（PCS）是一种具有多种表现形式的复杂多系统疾病。严重程度从轻度到非常严重不等，病程和恢复时间各异。本文讨论了定义和描述PCS的困难。我们回顾了目前对PCS的认识、流行病学及易感因素。我们考虑了包括病毒持续存在、凝血功能障碍和免疫在内的潜在机制。我们回顾了临床表现和诊断方法，最后考虑了管理策略，包括减轻症状负担、康复治疗和新疗法。
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