Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam Hospital, 73 Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Korea University College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2024 Feb 29;14(1):5053. doi: 10.1038/s41598-024-55434-6.
The risk of having atrial fibrillation (AF) is associated with alcohol intake. However, it is not clear whether sudden cardiac arrest (SCA) and ventricular arrhythmia (VA) including ventricular tachycardia, flutter, or fibrillation have similar associations with alcohol. We aimed to evaluate the association of alcohol intake with all-cause death, new-onset AF, VA, and SCA using single cohort with a sufficient sample size. A total of 3,990,373 people without a prior history of AF, VAs, or SCA was enrolled in this study based on nationwide health check-up in 2009. We classified the participants into four groups according to weekly alcohol consumption, and evaluated the association of alcohol consumption with each outcome. We observed a significant association between mild (hazard ratio [HR] = 0.826; 95% confidence interval [CI] = 0.815-0.838) to moderate (HR = 0.930; 95% CI = 0.912-0.947) drinking with decreased risk of all-cause mortality. However heavy drinking (HR = 1.108; 95% CI = 1.087-1.129) was associated with increased all-cause death. The risk of new-onset AF was significantly associated with moderate (HR = 1.129; 95% CI = 1.097-1.161) and heavy (HR = 1.298; 95% CI = 1.261-1.337) drinking. However, the risk of SCA showed negative association with all degrees of alcohol intake: 20% (HR = 0.803; 95% CI = 0.769-0.839), 15% (HR = 0.853; 95% CI = 0.806-0.902), and 8% (HR = 0.918; 95% CI = 0.866-0.974) lower risk for mild, moderate, and heavy drinkers, respectively. Mild drinking was associated with reduced risk of VA with moderate and heavy drinking having no associations. In conclusion, the association between alcohol and various outcomes in this study were heterogeneous. Alcohol might have different influences on various cardiac disorders.
患有心房颤动 (AF) 的风险与酒精摄入有关。然而，目前尚不清楚是否与酒精摄入相关的突发性心脏骤停 (SCA) 和室性心律失常 (VA)，包括室性心动过速、颤动或纤维性颤动有类似的关联。我们旨在使用具有足够样本量的单一队列来评估酒精摄入与全因死亡、新发房颤、VA 和 SCA 的相关性。
本研究共纳入了 2009 年全国健康检查中无房颤、VA 或 SCA 既往史的 3990373 人。根据每周饮酒量，将参与者分为四组，并评估饮酒与每种结果的关系。
我们观察到轻度（风险比 [HR] = 0.826；95%置信区间 [CI] = 0.815-0.838）至中度（HR = 0.930；95% CI = 0.912-0.947）饮酒与全因死亡率降低相关。然而，重度饮酒（HR = 1.108；95% CI = 1.087-1.129）与全因死亡风险增加相关。新发房颤的风险与中度（HR = 1.129；95% CI = 1.097-1.161）和重度（HR = 1.298；95% CI = 1.261-1.337）饮酒显著相关。然而，SCA 的风险与所有程度的酒精摄入呈负相关：20%（HR = 0.803；95% CI = 0.769-0.839）、15%（HR = 0.853；95% CI = 0.806-0.902）和 8%（HR = 0.918；95% CI = 0.866-0.974）的风险降低，分别为轻度、中度和重度饮酒者。轻度饮酒与 VA 风险降低相关，而中度和重度饮酒与 VA 无相关性。
总之，本研究中酒精与各种结局的相关性存在异质性。酒精可能对各种心脏疾病有不同的影响。
