Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.
Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.
Heart Rhythm. 2022 Feb;19(2):177-184. doi: 10.1016/j.hrthm.2021.09.040. Epub 2021 Dec 21.
Although previous studies have demonstrated a U-shaped relationship between alcohol and sudden cardiac death (SCD), there is a paucity of evidence on the role of alcohol specifically on incident ventricular arrhythmias (VAs).
The purpose of this study was to characterize associations of total and beverage-specific alcohol consumption with incident VA and SCD using data from the UK Biobank.
Alcohol consumption reported at baseline was calculated as UK standard drinks (8 g of alcohol) per week. Outcomes were assessed through hospitalization and death records. Alcohol consumption was modeled as restricted cubic splines in multivariate Cox regression models and corrected for regression dilution bias.
We studied 408,712 middle-aged individuals (52.1% female) over a median follow-up time of 11.5 years. A total of 1733 incident VA events and 2044 SCDs occurred. For incident VA, no clear association was seen with total alcohol consumption. Although consumption of greater amounts of spirits was associated with increased VA risk, no other significant beverage-specific associations were observed. For SCD, a U-shaped association was seen for total alcohol consumption, such that consumption of <26 drinks per week was associated with lowest risk. Consumption of greater amounts of beer, cider, and spirits was potentially associated with increasing SCD risk, whereas increasing red and white wine intake was associated with reduced risk.
In this predominantly white cohort, no association of total alcohol consumption was observed with VA, whereas a U-shaped association was present for SCD. Additional studies utilizing accurately defined VA and SCD events are required to provide further insights into these contrasting findings.
尽管先前的研究表明酒精与心源性猝死（SCD）之间存在 U 型关系，但关于酒精对室性心律失常（VA）事件发生的具体作用的证据很少。
本研究旨在使用英国生物库的数据，描述总饮酒量和特定酒类的饮酒量与 VA 和 SCD 事件的相关性。
以每周英国标准饮品（8 克酒精）为单位，计算基线时的饮酒量。通过住院和死亡记录评估结局。在多变量 Cox 回归模型中，采用受限立方样条对饮酒量进行建模，并校正回归稀释偏倚。
我们研究了 408712 名中年个体（52.1%为女性），中位随访时间为 11.5 年。共发生 1733 例 VA 事件和 2044 例 SCD。对于 VA 事件，总饮酒量与 VA 无明显相关性。尽管大量饮用烈酒与 VA 风险增加有关，但未观察到其他显著的特定酒类相关性。对于 SCD，总饮酒量呈 U 型相关性，每周饮酒量<26 杯与最低风险相关。饮用更多啤酒、苹果酒和烈酒可能与 SCD 风险增加有关，而增加红葡萄酒和白葡萄酒的摄入量与降低风险有关。
在这个以白种人为主的队列中，总饮酒量与 VA 之间无明显相关性，而 SCD 则呈 U 型相关性。需要进一步的研究来利用准确定义的 VA 和 SCD 事件，以提供对这些相互矛盾的发现的更深入了解。
