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糖尿病预防研究中出现的成年初期差距。

The emerging adulthood gap in diabetes prevention research.

作者信息

Arons Abigail, Seligman Hilary K

机构信息

Division of General Internal Medicine and Department of Pediatrics, UCSF, 490 Illinois Ave, Floor 7, San Francisco, CA, 94158, USA.

Center for Vulnerable Populations and Division of General Internal Medicine, UCSF, 490 Illinois Ave, Floor 7, San Francisco, CA, 94158, USA.

出版信息

Lancet Reg Health Am. 2024 Feb 25;32:100699. doi: 10.1016/j.lana.2024.100699. eCollection 2024 Apr.

Abstract

Emerging adulthood, the period between ages 18 and 25, is distinct from older and younger populations in terms of both physiology and social circumstances. As a critical developmental window with long-lasting repercussions, emerging adulthood presents a key opportunity for prevention of cardiovascular disease. Despite significant advances in diabetes and cardiovascular disease prevention for other age groups, 18-25 year-olds remain underrepresented in research. Using diabetes prevention as an example, we analyzed the cited evidence behind four major guidelines that influence US clinical practice on screening and management of prediabetes in children and adults, revealing that the majority of these studies in both the pediatric and adult literature do not include emerging adults in their study populations. This gap between the pediatric and adult diabetes prevention literature creates a missing link connecting childhood risks to adult chronic disease. In this article, we draw attention to this often overlooked age group, and provide tangible recommendations as a path forward for both pediatric and adult researchers to increase the representation of emerging adults in diabetes prevention and other cardiovascular disease prevention studies.

摘要

青年期(18至25岁)在生理和社会环境方面都与年龄较大和较小的人群有所不同。作为一个具有长期影响的关键发展窗口,青年期为预防心血管疾病提供了一个关键机会。尽管在糖尿病和心血管疾病预防方面,针对其他年龄组已经取得了重大进展,但18至25岁的人群在研究中的代表性仍然不足。以糖尿病预防为例,我们分析了影响美国儿童和成人糖尿病前期筛查和管理临床实践的四大指南背后所引用的证据,发现儿科和成人文献中的大多数研究在其研究人群中都没有纳入青年期人群。儿科和成人糖尿病预防文献之间的这一差距造成了将儿童期风险与成人慢性病联系起来的缺失环节。在本文中,我们提请人们关注这个经常被忽视的年龄组,并提供切实可行的建议,为儿科和成人研究人员增加青年期人群在糖尿病预防和其他心血管疾病预防研究中的代表性指明前进方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcd8/10904267/bc6de3f25d1a/gr1.jpg

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