Berry D H, Gloster E S, Jimenez J F, Grunow W A, Jordan R
Am J Pediatr Hematol Oncol. 1985 Summer;7(2):141-7.
Primary intracranial lymphoma is uncommon in any age group, but it is especially rare in childhood. This report describes a previously healthy, 14-month-old female infant who developed a primary intracranial immunoblastic (probable B-cell) lymphoma which remained confined to the central nervous system until the time of death, 23 months after diagnosis. She appears to be the youngest patient with documentation of such a diagnosis by light and electron microscopy and by histochemical and immunoperoxidase studies. An immunological investigation was negative. Significant maternal and paternal family histories of malignancy suggest that a genetic predisposition, combined with postzygotic events such as viral infection, may be responsible for this familial cluster of tumors, and for this patient's unusual presentation.
原发性颅内淋巴瘤在任何年龄组都不常见，但在儿童期尤为罕见。本报告描述了一名先前健康的14个月大女婴，她患了原发性颅内免疫母细胞性（可能是B细胞）淋巴瘤，在诊断后23个月死亡时，该淋巴瘤一直局限于中枢神经系统。她似乎是通过光镜和电镜以及组织化学和免疫过氧化物酶研究记录有此诊断的最年轻患者。免疫学检查为阴性。显著的母系和父系恶性肿瘤家族史表明，遗传易感性与病毒感染等合子后事件相结合，可能是导致这一肿瘤家族聚集以及该患者异常表现的原因。
