González F, Gómez C, Cabrera M E, Ayala A, Roessler E
Departamento de Medicina, Facultad de Medicina (Campus Oriente) Universidad de Chile, Hospital del Salvador, Santiago.
Rev Med Chil. 1994 Nov;122(11):1294-7.
We report a 30 year old male, presenting eight years after receiving a kidney transplant with intracranial hypertension and two hyperdense masses detected in a brain CAT scan, whose histopathological study revealed a giant cell immunoblastic lymphoma. The patient was successfully treated with chemo and radiotherapy and after 18 months of follow up there is no evidence of tumoral relapse. Immunocompromised patients, specially transplant recipients, had a several fold higher incidence of malignant tumors, specially primary lymphomas of the central nervous system. These are generally of B type, are associated to Epstein Barr virus and have a high mortality. Cancer must be considered in the differential diagnosis of masses of uncertain origin in transplant recipients.
我们报告了一名30岁男性，在接受肾移植8年后出现颅内高压，脑部计算机断层扫描（CAT）检测到两个高密度肿块，其组织病理学研究显示为巨细胞免疫母细胞淋巴瘤。该患者接受化疗和放疗后成功治愈，随访18个月后无肿瘤复发迹象。免疫功能低下的患者，特别是移植受者，患恶性肿瘤的几率高出数倍，尤其是中枢神经系统原发性淋巴瘤。这些淋巴瘤通常为B型，与爱泼斯坦-巴尔病毒有关，且死亡率很高。在移植受者中，对于来源不明的肿块进行鉴别诊断时必须考虑到癌症。
