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鉴定紧密连接蛋白-2作为糖尿病前期早期诊断的一种有前景的生物标志物。

Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes.

作者信息

Songtao Yang, Fangyu Li, Jie Cao, Li Yuan

机构信息

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Front Pharmacol. 2024 Feb 15;15:1370708. doi: 10.3389/fphar.2024.1370708. eCollection 2024.

DOI:10.3389/fphar.2024.1370708
PMID:38425650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10902111/
Abstract

Pre-diabetes, a high-risk metabolic state, is situated between normal glucose homeostasis and diabetes. Early identification of pre-diabetes offers opportunities for intervention and diabetes reversal, highlighting the crucial need to investigate reliable biomarkers for this condition. We conducted an in-depth bioinformatics analysis of clinical samples from non-diabetic (ND), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) categories within the GSE164416 dataset. Thereafter the HFD and STZ treated mice were used for validation. This analysis identified several codifferentially expressed genes (Co-DEGs) for IGT and T2DM, including , , , , , , , , , and . Validation of these genes and the determination of ROC curves were performed using the GSE76895 dataset. Thereafter, was selected for further verification. Gene expression analysis and immunofluorescence analysis revealed a significant upregulation of expression in the pancreas islets of mice in the high-fat diet and T2DM groups compared to the control group. Similarly, serum level of in patients with IGT and T2DM were significantly higher than those in the healthy group. These results suggest that can serve as a novel biomarker for pre-diabetes, providing a new direction for future research in the prevention of type 2 diabetes.

摘要

糖尿病前期是一种高危代谢状态，介于正常血糖稳态和糖尿病之间。早期识别糖尿病前期为干预和逆转糖尿病提供了机会，凸显了研究该病症可靠生物标志物的迫切需求。我们对GSE164416数据集中非糖尿病（ND）、糖耐量受损（IGT）和2型糖尿病（T2DM）类别的临床样本进行了深入的生物信息学分析。此后，使用高脂饮食和链脲佐菌素处理的小鼠进行验证。该分析确定了IGT和T2DM的几个共差异表达基因（Co-DEGs），包括 ， ， ， ， ， ， ， ， ，和 。使用GSE76895数据集对这些基因进行验证并确定ROC曲线。此后，选择 进行进一步验证。基因表达分析和免疫荧光分析显示，与对照组相比，高脂饮食和T2DM组小鼠胰岛中 表达显著上调。同样，IGT和T2DM患者的血清 水平显著高于健康组。这些结果表明， 可作为糖尿病前期的一种新型生物标志物，为未来2型糖尿病预防研究提供了新方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/9fd43e56170a/fphar-15-1370708-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/d5c177eddb5d/fphar-15-1370708-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/5efc081e4704/fphar-15-1370708-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/ba71d408155c/fphar-15-1370708-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/1d971f8d9185/fphar-15-1370708-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/f83d5189dd95/fphar-15-1370708-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/9fd43e56170a/fphar-15-1370708-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/d5c177eddb5d/fphar-15-1370708-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/5efc081e4704/fphar-15-1370708-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/ba71d408155c/fphar-15-1370708-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/1d971f8d9185/fphar-15-1370708-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/f83d5189dd95/fphar-15-1370708-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d251/10902111/9fd43e56170a/fphar-15-1370708-g006.jpg

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