树突状细胞特异性细胞间黏附分子3结合非整合素（DC-SIGN）对脂多糖（LPS）表位识别的原子水平剖析
Atomic-Level Dissection of DC-SIGN Recognition of LPS Epitopes.
作者信息
Nieto-Fabregat Ferran, Zhu Qian, Vivès Corinne, Zhang Yunqin, Marseglia Angela, Chiodo Fabrizio, Thépaut Michel, Rai Diksha, Kulkarni Suvarn S, Di Lorenzo Flaviana, Molinaro Antonio, Marchetti Roberta, Fieschi Franck, Xiao Guozhi, Yu Biao, Silipo Alba
机构信息
Department of Chemical Sciences, University of Naples Federico II, Naples 80126, Italy.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
JACS Au. 2024 Feb 12;4(2):697-712. doi: 10.1021/jacsau.3c00748. eCollection 2024 Feb 26.
The evaluation of mpk (BVMPK) lipopolysaccharide (LPS) recognition by DC-SIGN, a key lectin in mediating immune homeostasis, has been here performed. A fine chemical dissection of BVMPK LPS components, attained by synthetic chemistry combined to spectroscopic, biophysical, and computational techniques, allowed to finely map the LPS epitopes recognized by DC-SIGN. Our findings reveal BVMPK's role in immune modulation via DC-SIGN, targeting both the LPS O-antigen and the core oligosaccharide. Furthermore, when framed within medical chemistry or drug design, our results could lead to the development of tailored molecules to benefit the hosts dealing with inflammatory diseases.
我们在此对介导免疫稳态的关键凝集素DC-SIGN对mpk（BVMPK）脂多糖（LPS）的识别进行了评估。通过将合成化学与光谱、生物物理和计算技术相结合，对BVMPK LPS成分进行精细的化学剖析，从而能够精确绘制出DC-SIGN识别的LPS表位。我们的研究结果揭示了BVMPK通过DC-SIGN在免疫调节中的作用，其靶向LPS O抗原和核心寡糖。此外，从药物化学或药物设计的角度来看，我们的结果可能会促使开发定制分子，以造福于患有炎症性疾病的宿主。
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