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1例罕见的累及眼眶的胃结外NK/T细胞淋巴瘤

A Rare Case of Gastric Extranodal NK/T-Cell Lymphoma With Orbital Involvement.

作者信息

Zhao Billy, Kim Hyun Jae, Tam Landon, Xiong Wei, Rosenfeld Greg

机构信息

Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

ACG Case Rep J. 2024 Feb 28;11(3):e01280. doi: 10.14309/crj.0000000000001280. eCollection 2024 Mar.

DOI:10.14309/crj.0000000000001280
PMID:38425941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10901430/
Abstract

Gastric extranodal NK/T-cell lymphoma (ENKTL) is a rare presentation of a rare disease. We report a 33-year-old woman presenting with epigastric pain, nausea, and vomiting. Endoscopic examination revealed gastric and duodenal ulceration. Biopsy of the ulcers revealed ENKTL. The patient began treatment, but developed hemorrhagic shock from her ulcers and died. Gastric ENKTL is a rare disease that presents with gastric ulceration. It has a high rate of mortality, and treatment is challenging because of its aggressive nature and lack of high-quality data to guide therapy.

摘要

胃结外NK/T细胞淋巴瘤（ENKTL）是一种罕见疾病的罕见表现形式。我们报告一名33岁女性，出现上腹部疼痛、恶心和呕吐症状。内镜检查发现胃和十二指肠溃疡。溃疡活检显示为ENKTL。患者开始接受治疗，但因溃疡引发失血性休克并死亡。胃ENKTL是一种以胃溃疡为表现的罕见疾病。其死亡率很高，由于其侵袭性以及缺乏高质量数据来指导治疗，治疗具有挑战性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/42140a8172d7/ac9-11-e01280-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/8b182a15176b/ac9-11-e01280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/1d90392e45f7/ac9-11-e01280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/44859170ecca/ac9-11-e01280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/7387c8376527/ac9-11-e01280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/42140a8172d7/ac9-11-e01280-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/8b182a15176b/ac9-11-e01280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/1d90392e45f7/ac9-11-e01280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/44859170ecca/ac9-11-e01280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/7387c8376527/ac9-11-e01280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59e0/10901430/42140a8172d7/ac9-11-e01280-g005.jpg

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本文引用的文献

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Gastric CD56-negative Extranodal Natural Killer/T-cell Lymphoma: A Case Report.胃 CD56 阴性结外自然杀伤/T 细胞淋巴瘤：一例报告。
Korean J Gastroenterol. 2022 Oct 25;80(4):190-194. doi: 10.4166/kjg.2022.076.
2
How we treat NK/T-cell lymphomas.我们如何治疗 NK/T 细胞淋巴瘤。
J Hematol Oncol. 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5.
3
Primary breast CD20-positive extranodal NK/T cell lymphoma with stomach involvement: a case report and literature review.原发乳腺 CD20 阳性结外 NK/T 细胞淋巴瘤累及胃：一例报告并文献复习。
Diagn Pathol. 2021 Nov 8;16(1):103. doi: 10.1186/s13000-021-01166-4.
4
Primary Gastrointestinal T/NK Cell Lymphoma.原发性胃肠道T/NK细胞淋巴瘤
Cancers (Basel). 2021 May 29;13(11):2679. doi: 10.3390/cancers13112679.
5
Gastrointestinal T- and NK-cell lymphomas and indolent lymphoproliferative disorders.胃肠道 T 细胞和 NK 细胞淋巴瘤和惰性淋巴增殖性疾病。
Semin Diagn Pathol. 2020 Jan;37(1):11-23. doi: 10.1053/j.semdp.2019.08.001. Epub 2019 Aug 28.
6
Extranodal NK/T-cell lymphoma mimicking Crohn's colitis.模仿克罗恩病性结肠炎的结外NK/T细胞淋巴瘤
Malays J Pathol. 2019 Aug;41(2):195-199.
7
Clinical characteristics of primary intestinal NK/T cell lymphoma, nasal type: Case series and review of the literature.鼻型原发性肠道NK/T细胞淋巴瘤的临床特征：病例系列及文献综述
Pathol Res Pract. 2018 Aug;214(8):1081-1086. doi: 10.1016/j.prp.2018.05.013. Epub 2018 May 25.
8
Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases.结外NK/T细胞淋巴瘤，鼻型（ENKTL-NT）：北美和欧洲病例的流行病学、临床表现及自然史最新进展
Curr Hematol Malig Rep. 2016 Dec;11(6):514-527. doi: 10.1007/s11899-016-0355-9.
9
Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report.原发性胃自然杀伤/T细胞淋巴瘤伴弥漫性CD30表达且无CD56表达：一例报告
Oncol Lett. 2016 Feb;11(2):969-972. doi: 10.3892/ol.2015.4015. Epub 2015 Dec 9.
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Primary gastric extranodal natural killer/T-cell lymphoma, nasal type, with acquisition of CD20 expression in the subcutaneous relapse: report of a case with literature review.原发性胃结外自然杀伤/T细胞淋巴瘤，鼻型，皮下复发时获得CD20表达：1例报告并文献复习
J Clin Pathol. 2015 Nov;68(11):943-5. doi: 10.1136/jclinpath-2015-203188. Epub 2015 Jul 3.