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Proteogenomic profiling uncovers differential therapeutic vulnerabilities between and translocated B-cell acute lymphoblastic leukemia.

作者信息

Blumel Lena, Bernardi Flavia, Picard Daniel, Diaz Jacob Torrejon, Jepsen Vera H, Hasselmann Rebecca, Schliehe-Diecks Julian, Bartl Jasmin, Qin Nan, Bornhauser Beat, Bhatia Sanil, Marovka Blerim, Marsaud Veronique, Dingli Florent, Loew Damarys, Stanulla Martin, Bourqin Jean-Pierre, Borkhardt Arndt, Remke Marc, Ayrault Olivier, Fischer Ute

机构信息

Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Dusseldorf, Medical Faculty, and University Hospital Dusseldorf, Dusseldorf, Germany; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen/Dusseldorf, Dusseldorf.

Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Universite Paris Sud, Universite Paris-Saclay, Orsay.

出版信息

Haematologica. 2024 Jul 1;109(7):2290-2296. doi: 10.3324/haematol.2023.283928.

DOI:10.3324/haematol.2023.283928
PMID:38426288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11215373/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/879564dcfa16/1092290.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/f7add1bedd32/1092290.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/5bbc30e2fe47/1092290.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/879564dcfa16/1092290.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/f7add1bedd32/1092290.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/5bbc30e2fe47/1092290.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59b4/11215373/879564dcfa16/1092290.fig3.jpg

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Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK).发现选择性不可逆的 B 淋巴细胞酪氨酸激酶(BLK)抑制剂。
Eur J Med Chem. 2022 Feb 5;229:114051. doi: 10.1016/j.ejmech.2021.114051. Epub 2021 Dec 16.
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The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences.
PRIDE 数据库资源在 2022 年:一个基于质谱的蛋白质组学证据的中心。
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552. doi: 10.1093/nar/gkab1038.
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Ibrutinib is not an effective drug in primografts of TCF3-PBX1.依鲁替尼在TCF3-PBX1的原始移植物中不是一种有效的药物。
Transl Oncol. 2020 Oct;13(10):100817. doi: 10.1016/j.tranon.2020.100817. Epub 2020 Jun 18.
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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.白血病相关的 TCF3-HLF 复合物重塑增强子驱动细胞身份和自我更新,赋予 EP300 易感性。
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