Department of Pharmacology, Delhi Pharmaceutical Science and Research University (DPSRU), New Delhi, India.
Centre for Precision Medicine and Pharmacy, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India.
Methods Mol Biol. 2024;2761:159-179. doi: 10.1007/978-1-0716-3662-6_13.
Network pharmacology is an emerging pioneering approach in the drug discovery process, which is used to predict the therapeutic mechanism of compounds using various bioinformatic tools and databases. Emerging studies have indicated the use of network pharmacological approaches in various research fields, particularly in the identification of possible mechanisms of herbal compounds/ayurvedic formulations in the management of various diseases. These techniques could also play an important role in the prediction of the possible mechanisms of neuroprotective compounds. The first part of the chapter includes an introduction on neuroprotective compounds based on literature. Further, network pharmacological approaches are briefly discussed. The use of network pharmacology in the prediction of the neuroprotective mechanism of compounds is discussed in detail with suitable examples. Finally, the chapter concludes with the current challenges and future prospectives.
网络药理学是药物发现过程中的一种新兴的开创性方法，它使用各种生物信息学工具和数据库来预测化合物的治疗机制。新兴研究表明，网络药理学方法在各个研究领域都有应用，特别是在确定草药化合物/阿育吠陀配方在各种疾病管理中的可能机制方面。这些技术在预测神经保护化合物的可能机制方面也可能发挥重要作用。本章的第一部分包括基于文献的神经保护化合物的介绍。此外，还简要讨论了网络药理学方法。详细讨论了网络药理学在预测化合物的神经保护机制中的应用，并结合合适的例子进行了说明。最后，本章总结了当前的挑战和未来的展望。
