Department of Pathology, Jorhat Medical College and Hospital, Jorhat, Assam, India.
Department of Pathology, Tezpur Medical College and Hospital, Jorhat, Assam, India.
Indian J Pathol Microbiol. 2024 Apr 1;67(2):340-348. doi: 10.4103/ijpm.ijpm_426_23. Epub 2024 Feb 19.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with 878,348 new cases. Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor stroma and are important promoters of tumor progression.
The aim of the study was to evaluate the pattern of desmoplastic stromal reaction and peri-tumoral inflammatory infiltrate with the histological grade and clinical data.
A total of 60 cases of HNSCC were included in the study. The hematoxylin and eosin (H and E)-stained sections from all cases were examined by two experienced pathologists for the grade, nature of stomal reaction (SR), peri-tumoral inflammatory infiltration, Yamamoto-Kohama classification grade, worst pattern of invasion (WPOI), depth of invasion (DOI), and other histopathological parameters. Correlation analysis was conducted using the Chi-square test. P- value less than 0.05 was considered statistically significant.
Immature SR was not observed in any of the well-differentiated squamous cell carcinoma (SCC) cases. However, one (3.7%) case of moderately differentiated SCC and two (28.6%) cases of poorly differentiated SCC showed signs of immature SR. In the case of the higher grades of the YK classification, specifically grades 4C and 4D, a more profound depth of tumor cell invasion, equal to or exceeding 10 mm, was evident in six (66.67%) and two (28.57%) cases, respectively. Additionally, among the seven (11.7%) cases classified as poorly differentiated carcinoma, three (42.85%) displayed a WPOI score of 5.
SR and the tumor invasive pattern in HNSCC are related to prognosis and may indicate tumor aggressiveness.
头颈部鳞状细胞癌（HNSCC）是全球第六大常见癌症，新发病例 878348 例。癌相关成纤维细胞（CAF）是肿瘤基质中主要的细胞类型，是肿瘤进展的重要促进因素。
本研究旨在评估肿瘤间质的促结缔组织增生反应和肿瘤周围炎症浸润的模式与组织学分级和临床资料的关系。
共纳入 60 例 HNSCC 病例。两名有经验的病理学家对所有病例的苏木精和伊红（H&E）染色切片进行检查，评估分级、基质反应（SR）性质、肿瘤周围炎症浸润、Yamamoto-Kohama 分级、最差浸润模式（WPOI）、浸润深度（DOI）和其他组织病理学参数。采用卡方检验进行相关性分析。P 值小于 0.05 为统计学显著。
在任何分化良好的鳞状细胞癌（SCC）病例中均未观察到不成熟的 SR。然而，1 例（3.7%）中分化 SCC 和 2 例（28.6%）低分化 SCC 出现不成熟 SR 的迹象。在 YK 分级较高的等级，特别是 4C 和 4D 级，6 例（66.67%）和 2 例（28.57%）分别有更明显的肿瘤细胞浸润深度，等于或超过 10mm。此外，在 7 例（11.7%）分类为低分化癌的病例中，有 3 例（42.85%）WPOI 评分达到 5 分。
HNSCC 中的 SR 和肿瘤浸润模式与预后相关，可能提示肿瘤侵袭性。
