Manchikanti L, Colliver J A, Marrero T C, Roush J R
Anesth Analg. 1985 Jan;64(1):11-7.
One hundred inpatients scheduled for elective surgery were studied to determine the age-related risk of pulmonary aspiration as indicated by gastric acidity and volume. Twenty-five patients from 6 months to 12 years old were included in the pediatric age group, 50 patients from 18 to 64 years old were included in the adult age group, and 25 patients older than 65 years old were included in the geriatric group. Mean gastric pH was 1.99, 2.40, and 3.32 in the pediatric, adult, and geriatric age groups, respectively; the differences between the three groups were statistically significant. The proportions of patients with pH less than or equal to 2.50 were also significantly different among three groups: 92%, 76%, and 60% in the pediatric, adult, and geriatric age groups, respectively. Mean gastric volumes were 0.49, 0.37, and 0.24 ml/kg and proportions of patients with volumes greater than or equal to 0.40 ml/kg were 60, 32, and 12% in pediatric, adult, and geriatric patients, respectively. Gastric contents with both pH less than or equal to 2.5 and volume greater than or equal to 0.4 ml/kg were seen in 60, 28, and 12% in the three respective groups. Risk of acid aspiration pneumonitis theoretically is present in all age groups, with children being at greatest risk and geriatric patients with least risk. We have also noted a correlation between age and gastric contents because gastric acidity and volume both decreased as age increased. Increasing length of fasting period increased gastric acidity without significant effect on volume.
对100例计划进行择期手术的住院患者进行了研究,以确定根据胃酸度和容量所显示的与年龄相关的肺误吸风险。6个月至12岁的25例患者纳入儿科年龄组,18至64岁的50例患者纳入成人年龄组,65岁以上的25例患者纳入老年组。儿科、成人和老年年龄组的平均胃pH值分别为1.99、2.40和3.32;三组之间的差异具有统计学意义。三组中pH值小于或等于2.50的患者比例也有显著差异:儿科、成人和老年年龄组分别为92%、76%和60%。平均胃容量分别为0.49、0.37和0.24 ml/kg,胃容量大于或等于0.40 ml/kg的患者比例在儿科、成人和老年患者中分别为60%、32%和12%。胃内容物pH值小于或等于2.5且容量大于或等于0.4 ml/kg的情况在三组中分别为60%、28%和12%。理论上,所有年龄组都存在酸性误吸性肺炎的风险,儿童风险最大,老年患者风险最小。我们还注意到年龄与胃内容物之间的相关性,因为随着年龄的增加,胃酸度和容量均降低。禁食时间延长会增加胃酸度,但对容量无显著影响。