肿瘤中的代谢性细胞死亡：铁死亡、铜死亡、二硫键依赖的细胞死亡及其他。
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond.
机构信息
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Protein Cell. 2024 Sep 1;15(9):642-660. doi: 10.1093/procel/pwae003.
Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism. This review discusses the mechanisms of metabolic cell death-ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis-and explores their potential in cancer therapy. Our review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.
细胞死亡抵抗是癌症的一个标志。最近的研究已经确定代谢性细胞死亡是一种独特的细胞死亡形式，是由于细胞代谢失衡而导致的。本文讨论了代谢性细胞死亡——铁死亡、铜死亡、二硫键依赖的细胞死亡、溶酶体锌死亡和碱中毒性细胞死亡的机制，并探讨了它们在癌症治疗中的潜在应用。我们的综述强调了代谢性细胞死亡途径的复杂性，并为癌症治疗的创新治疗途径提供了新的思路。
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