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Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.

作者信息

Mao Chao, Liu Xiaoguang, Yan Yuelong, Olszewski Kellen, Gan Boyi

机构信息

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The Barer Institute, Philadelphia, PA, USA.

出版信息

Nature. 2023 Jul;619(7968):E19-E23. doi: 10.1038/s41586-023-06270-7.

DOI:10.1038/s41586-023-06270-7
PMID:37407682
Abstract
摘要

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Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.回复：二氢乳清酸脱氢酶（DHODH）抑制剂通过抑制铁死亡抑制蛋白1（FSP1）使细胞对铁死亡敏感。
Nature. 2023 Jul;619(7968):E19-E23. doi: 10.1038/s41586-023-06270-7.
2
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本文引用的文献

1
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.铁死亡研究十周年：新兴机制、生理功能与治疗应用
Cell. 2022 Jul 7;185(14):2401-2421. doi: 10.1016/j.cell.2022.06.003.
2
A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria.线粒体中甘油-3-磷酸脱氢酶 2 介导的铁死亡防御机制。
Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2121987119. doi: 10.1073/pnas.2121987119. Epub 2022 Jun 24.
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Mitochondrial regulation of ferroptosis.线粒体对铁死亡的调控。
Front Pharmacol. 2025 Apr 3;16:1557133. doi: 10.3389/fphar.2025.1557133. eCollection 2025.
4
Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress.真核生物翻译起始因子2α（eIF2α）的磷酸化可抑制内质网应激期间谷胱甘肽/烟酰胺腺嘌呤二核苷酸磷酸（GSH/NADPH）稳态的损伤，并减轻包括铁死亡在内的细胞死亡途径的激活。
Mol Cells. 2025 May;48(5):100210. doi: 10.1016/j.mocell.2025.100210. Epub 2025 Mar 13.
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Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.关于细胞半胱氨酸来源及其与铁死亡可能关系的未解决问题。
Adv Cancer Res. 2024;162:1-44. doi: 10.1016/bs.acr.2024.04.001. Epub 2024 May 3.
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Ferroptotic therapy in cancer: benefits, side effects, and risks.铁死亡疗法在癌症中的应用：获益、副作用和风险。
Mol Cancer. 2024 May 3;23(1):89. doi: 10.1186/s12943-024-01999-9.
7
Unlocking ferroptosis in prostate cancer - the road to novel therapies and imaging markers.解锁前列腺癌中的铁死亡——通向新型治疗方法和成像标志物的道路。
Nat Rev Urol. 2024 Oct;21(10):615-637. doi: 10.1038/s41585-024-00869-9. Epub 2024 Apr 16.
8
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.国际共识指南：自噬依赖性铁死亡的定义、检测和解释。
Autophagy. 2024 Jun;20(6):1213-1246. doi: 10.1080/15548627.2024.2319901. Epub 2024 Mar 24.
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Ironing out the details of ferroptosis.解决铁死亡的细节问题。
Nat Cell Biol. 2024 Sep;26(9):1386-1393. doi: 10.1038/s41556-024-01361-7. Epub 2024 Mar 1.
10
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond.肿瘤中的代谢性细胞死亡：铁死亡、铜死亡、二硫键依赖的细胞死亡及其他。
Protein Cell. 2024 Sep 1;15(9):642-660. doi: 10.1093/procel/pwae003.
J Cell Biol. 2021 Sep 6;220(9). doi: 10.1083/jcb.202105043. Epub 2021 Jul 30.
4
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.DHODH 介导的铁死亡防御是癌症的一个可靶向弱点。
Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12.
5
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.辅酶 Q 氧化还原酶 FSP1 与 GPX4 平行作用以抑制铁死亡。
Nature. 2019 Nov;575(7784):688-692. doi: 10.1038/s41586-019-1705-2. Epub 2019 Oct 21.
6
FSP1 is a glutathione-independent ferroptosis suppressor.FSP1 是一种谷胱甘肽不依赖的铁死亡抑制因子。
Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21.
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Ferroptosis: an iron-dependent form of nonapoptotic cell death.铁死亡：一种依赖于铁的非细胞凋亡性细胞死亡形式。
Cell. 2012 May 25;149(5):1060-72. doi: 10.1016/j.cell.2012.03.042.
8
Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions.短型谷胱甘肽过氧化物酶4是生存和体细胞线粒体功能所需的必需同工型。
J Biol Chem. 2009 Nov 6;284(45):30836-44. doi: 10.1074/jbc.M109.032839. Epub 2009 Sep 10.