Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona, Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain; CIBERSAM, ISCIII, Madrid, Spain; Institut d'Investigacions Biomèdiques, August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
CIBERSAM, ISCIII, Madrid, Spain; Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocio-IBIS, Sevilla, Spain.
Schizophr Res. 2024 Apr;266:216-226. doi: 10.1016/j.schres.2024.02.020. Epub 2024 Feb 29.
Patients with schizophrenia exhibit a reduced life expectancy mainly due to medical-related pathologies which might have been initiated due to stressful events during fetal development. Indeed, intra-uterus growth patterns predict anthropometric measures in adulthood, describing risk factors for schizophrenia and metabolic disorders. We aim to evaluate anthropometric values in two cohorts of antipsychotic-naïve first-episode episode psychosis (FEP) and correlated them with surrogate markers of the fetal environment such as birth weight (BW) and season of birth.
BW, season of birth, and anthropometric values from 2 cohorts of FEP patients (Barcelona and Santander) were evaluated. In cohort B, 91 patients, and 110 controls while in cohort S, 644 and 235 were included respectively.
Patients were shorter, slimmer, and with lower BMI compared with controls. In both cohorts, patients, and female patients born in winter displayed the shortest height. Regarding BW, height was significantly associated with the interaction of diagnosis and BW in the whole sample and the male subsample.
Our results confirm reduced anthropometric features in FEP at onset while suggesting the influence of winter birth and BW, highlighting the role of early life events in the later outcome of FEP with sex differences.
精神分裂症患者的预期寿命较短，主要是由于与医学相关的病理，这些病理可能是由于胎儿发育过程中的应激事件而引发的。事实上，子宫内的生长模式可以预测成年后的人体测量指标，这些指标描述了精神分裂症和代谢紊乱的风险因素。我们旨在评估两个抗精神病药物初发精神分裂症（FEP）队列的人体测量值，并将其与胎儿环境的替代标志物（如出生体重（BW）和出生季节）相关联。
评估了来自巴塞罗那和桑坦德两个 FEP 患者队列的 BW、出生季节和人体测量值。在队列 B 中，有 91 名患者和 110 名对照，而在队列 S 中，分别有 644 名和 235 名患者。
与对照组相比，患者的身高较矮、体型较瘦、BMI 较低。在两个队列中，冬季出生的患者和女性患者身高最短。关于 BW，身高与整个样本和男性亚样本中诊断和 BW 的交互作用显著相关。
我们的结果证实了 FEP 发病时的人体测量特征减少，同时表明冬季出生和 BW 的影响，突出了生命早期事件在 FEP 后期结果中的作用，具有性别差异。
