Garcia-Rizo Clemente, Bitanihirwe Byron K Y
Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
Institute of Biomedical Research Agusti Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Mol Psychiatry. 2025 Jul 11. doi: 10.1038/s41380-025-03096-9.
Exposure to perinatal stress has been linked to the later emergence of mental health problems including neurodevelopmental disorders such as psychosis. Recent research highlights not only an increased risk of psychotic illness in offspring following perinatal maternal life events but also the future manifestation of diverse epiphenomena. These epiphenomena include metabolic disturbances, structural brain abnormalities, and cognitive impairment in addition to distinct psychopathological profiles involving motor and physical anomalies. Our aim here lies in discussing the different clinical features of psychosis as they emerge at onset and during the evolution of the disease-from a translational perspective-in terms of perinatal stressful experiences. A hypothetical model of metabolic manifestations that are present in adulthood stemming from perinatal events will be elaborated to provide a partial explanation of the increased morbidity and early mortality observed in patients who develop psychosis. This model will encompass aspects related to brain structural abnormalities, clinical psychopathological characteristics and the cognitive impairment typically observed in individuals with psychotic disorders. We also put forward a framework that encapsulates the 'scars' of perinatal stressful experiences associated with psychosis in terms of a public health agenda.
围产期应激与包括精神病等神经发育障碍在内的心理健康问题的后期出现有关。最近的研究不仅强调围产期母亲生活事件后后代患精神病性疾病的风险增加，还强调了各种附带现象的未来表现。这些附带现象包括代谢紊乱、脑结构异常和认知障碍，此外还有涉及运动和身体异常的独特精神病理学特征。我们在此的目的是从转化的角度，就围产期应激经历来讨论精神病在发病时和疾病演变过程中出现的不同临床特征。将阐述一个源于围产期事件的成年期代谢表现的假设模型，以部分解释在患精神病的患者中观察到的发病率增加和早期死亡率。该模型将涵盖与脑结构异常、临床精神病理学特征以及通常在精神病性障碍患者中观察到的认知障碍相关的方面。我们还提出了一个框架，从公共卫生议程的角度概括与精神病相关的围产期应激经历的“创伤”。
