Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Bern, Fabrikstrasse 8, 3012 Bern, Switzerland.
Translational Research Center, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland; Graduate School of Health Sciences, University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland.
Conscious Cogn. 2024 Mar;119:103667. doi: 10.1016/j.concog.2024.103667. Epub 2024 Feb 29.
The sense of agency (SoA) is central to human experience. The comparator model, contrasting sensory prediction and action feedback, is influential but limited in explaining SoA. We investigated mechanisms beyond the comparator model, focusing on the processing of unpredictable stimuli, perimotor components of SoA, and their relation to schizotypy. ERPs were recorded from 18 healthy participants engaged in button-pressing tasks while perceiving tones with varying causal relationships with their actions. We investigated the processing of non-causally related tones, contrasted this to causally related tones, and examined perimotor correlates of subjective expectancy and experience of agency. We confirmed N100 attenuation for self-generated stimuli but found similar effects for expectancy-dependent processing of random tones. SoA also correlated with perimotor ERP components, modulated by schizotypy. Thus, neural processes preceding actions contribute to the formation of SoA and are associated with schizotypy. Unpredictable events also undergo sensory attenuation, implying additional mechanisms contributing to SoA.
主体感（SoA）是人类体验的核心。对比感觉预测和动作反馈的比较器模型虽然具有影响力，但在解释主体感方面存在局限性。我们研究了超越比较器模型的机制，重点关注不可预测刺激的处理、主体感的运动前成分及其与精神分裂症倾向的关系。我们记录了 18 名健康参与者在进行按钮按压任务时的 ERP，同时感知与动作相关的不同因果关系的音调。我们研究了非因果相关音调的处理，将其与因果相关音调进行对比，并检查了运动前成分与主观预期和代理体验的关系。我们证实了自我产生刺激的 N100 衰减，但对随机音调的期望相关处理也发现了类似的效果。主体感还与运动前 ERP 成分相关，受精神分裂症倾向调节。因此，动作前的神经过程有助于主体感的形成，并与精神分裂症倾向有关。不可预测的事件也经历感觉衰减，这意味着主体感形成的其他机制。
