Department of Spine Surgery, Ganzhou People’s Hospital, Ganzhou, Jiangxi, China.
Aging (Albany NY). 2024 Feb 28;16(5):4579-4590. doi: 10.18632/aging.205614.
Osteosarcoma is a cancer originating in the bone cells, specifically in the osteoblasts. Previous studies mainly focused on particular molecules but the whole pathway network. We comprehensively analyzed the enrichment score of each signal pathway and identified a novel classification by 20 machine learning algorithms. Furthermore, differences in tumor immune infiltration cells and drug sensitivity were compared in low and high groups. We identified a model consisting of four signaling pathways that predict the prognosis and the immune status of the tumor microenvironment and drug sensitivity in osteosarcoma patients. The novel classification may be used in clinical applications to predict prognosis and drug sensitivity.
骨肉瘤是一种起源于骨细胞的癌症，特别是成骨细胞。之前的研究主要集中在特定的分子上，但我们全面分析了每条信号通路的富集评分，并通过 20 种机器学习算法确定了一种新的分类。此外，我们还比较了低分组和高分组肿瘤免疫浸润细胞和药物敏感性的差异。我们确定了一个由四个信号通路组成的模型，该模型可以预测骨肉瘤患者的预后和肿瘤微环境的免疫状态以及药物敏感性。这种新的分类方法可能会用于临床应用，以预测预后和药物敏感性。
