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希尔德·芒戈尔德:原胃腔组织者实验的显微镜载玻片和记录。

Hilde Mangold: Original microscope slides and records of the gastrula organizer experiments.

机构信息

Developmental Biology, Institute Biology 1, Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany; CIBSS and BIOSS - Centres for Biological Signalling Studies, University of Freiburg, Freiburg im Breisgau, Germany.

Developmental Biology, Institute Biology 1, Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.

出版信息

Cells Dev. 2024 Jun;178:203909. doi: 10.1016/j.cdev.2024.203909. Epub 2024 Feb 28.

Abstract

The discovery of the amphibian gastrula organizer and its publication by Hans Spemann and Hilde Mangold in 1924 is a foundation of experimental embryology, and has shaped our understanding of embryonic induction and pattern formation in vertebrates until today. The original publication is a piece of scientific art, characterized by the meticulous hand drawings by Hilde Mangold, as well as the text that develops mechanistic concepts of modern embryology. While historic microphotographs of specimens got lost, the original microscope slides and Hilde Mangold's laboratory notebook have been secured in embryological collections until today. Here, we make the original data of the six embryonic specimens reported in 1924, as well as the laboratory notebook, available in an accessible digital format. Together, these data shed light on the scientific process that led to the discovery, and should help to make the experiments on the most important signalling center in early vertebrate development transparent for generations of embryologists to come.

摘要

1924 年,汉斯·斯佩曼(Hans Spemann)和希尔德·芒戈尔德(Hilde Mangold)发现了两栖类胚囊组织者,并将其发表,这一发现奠定了实验胚胎学的基础,并一直影响着我们对脊椎动物胚胎诱导和模式形成的理解。原始出版物是一件科学艺术品,其特点是希尔德·芒戈尔德(Hilde Mangold)精心绘制的手绘图,以及阐述现代胚胎学机械论概念的文本。虽然原始的标本显微照片已经丢失,但原始的显微镜载玻片和希尔德·芒戈尔德的实验室笔记本至今仍保存在胚胎学收藏中。在这里,我们以可访问的数字格式提供了 1924 年报告的六个胚胎标本的原始数据以及实验室笔记本。这些数据共同揭示了导致这一发现的科学过程,应该有助于使早期脊椎动物发育中最重要的信号中心的实验对未来几代胚胎学家来说变得透明。

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