Health Science Center, Ningbo University, Ningbo, China.
Department of Dermatology, the First Affiliated Hospital of Ningbo University, Ningbo, China.
Biochem Pharmacol. 2024 Apr;222:116100. doi: 10.1016/j.bcp.2024.116100. Epub 2024 Feb 29.
V-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, including neutrophils, monocytes, macrophages, dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs). In addition, we will discuss whether the functions of VISTA on these cells impact the disease processing.
V 结构域包含 Ig 抑制 T 细胞活化因子（VISTA）主要表达在髓系细胞上，作为配体/受体/可溶性分子发挥作用。在炎症反应和免疫反应中，VISTA 调节髓系细胞的多种功能，如趋化性、吞噬作用、T 细胞活化。由于炎症和免疫反应在许多疾病中至关重要，VISTA 是一个很有前途的治疗靶点。在这篇综述中，我们将描述 VISTA 在不同髓系细胞（包括中性粒细胞、单核细胞、巨噬细胞、树突状细胞（DCs）、髓系来源的抑制细胞（MDSCs））上的表达和功能。此外，我们还将讨论 VISTA 在这些细胞上的功能是否影响疾病的发生。
