Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Int Dent J. 2024 Aug;74(4):688-695. doi: 10.1016/j.identj.2024.01.029. Epub 2024 Mar 1.
The aim of this scoping review was to explore and synthesise the current evidence on the antimicrobial activity of antibacterial suture materials used in oral surgery.
The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. A bibliographic search was carried out in the PubMed and Scopus databases to retrieve all human clinical studies that investigated the antimicrobial efficacy of antibacterial-coated sutures used in oral surgery. Included studies were screened and extracted independently by 2 examiners. Data were tabulated and qualitatively described.
The search initially returned 150 articles and resulted in 5 included studies after the duplicates' removal and the full-text screening. Selected studies were published from 2014 to 2019. Three studies (60%) were randomised clinical trials, whilst the remaining studies did not report information on randomisation. The antimicrobial agents for coated sutures included triclosan and chlorhexidine. In almost all the studies, antibacterial-coated sutures exhibited lower bacterial retention compared to those without coating.
Within limitations, the antimicrobial-coated sutures employed in oral surgery exhibited good results in terms of their microbicidal activity when compared with sutures that were not coated. Considering the high variability and confounding factors identified in the included studies, more high-quality research is needed to confirm these results. Antimicrobial-coated sutures could represent a promising and clinically valid strategy to reduce microbial colonisation in oral surgery. The reduced bacterial adherence is likely to improve the clinical success of the surgical procedures. Yet, the cost-benefit ratio of antimicrobial-coated sutures should be assessed in larger clinical trials to confirm their efficacy over conventional noncoated sutures.
本系统评价旨在探索和综合目前关于口腔外科使用的抗菌缝线材料的抗菌活性的证据。
本评价遵循系统评价和荟萃分析的首选报告项目（PRISMA）扩展范围评价进行。在 PubMed 和 Scopus 数据库中进行文献检索，以检索所有调查口腔外科使用的抗菌涂层缝线的抗菌功效的人类临床研究。由 2 名审查员独立筛选和提取纳入研究。对数据进行制表和定性描述。
最初的检索返回了 150 篇文章，经过去除重复项和全文筛选后，有 5 项研究被纳入。入选研究发表于 2014 年至 2019 年。其中 3 项研究（60%）为随机临床试验，而其余研究未报告随机化信息。涂层缝线使用的抗菌剂包括三氯生和洗必泰。在几乎所有研究中，抗菌涂层缝线的细菌保留率均低于未涂层缝线。
在一定限制内，与未涂层缝线相比，口腔外科中使用的抗菌涂层缝线在杀菌活性方面表现出良好的效果。考虑到纳入研究中确定的高变异性和混杂因素，需要更多高质量的研究来证实这些结果。抗菌涂层缝线可能代表一种有前途且在临床上有效的策略，可以减少口腔外科中的微生物定植。减少细菌黏附可能会提高手术程序的临床成功率。然而，需要在更大的临床试验中评估抗菌涂层缝线的成本效益比，以确认其相对于传统非涂层缝线的疗效。
